ID   PHMT_MYCBP              Reviewed;         270 AA.
AC   A1KMU6;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=BCG_2973;
OS   Mycobacterium bovis (strain BCG / Pasteur 1173P2).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=410289;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BCG / Pasteur 1173P2;
RX   PubMed=17372194; DOI=10.1073/pnas.0700869104;
RA   Brosch R., Gordon S.V., Garnier T., Eiglmeier K., Frigui W., Valenti P.,
RA   Dos Santos S., Duthoy S., Lacroix C., Garcia-Pelayo C., Inwald J.K.,
RA   Golby P., Garcia J.N., Hewinson R.G., Behr M.A., Quail M.A., Churcher C.,
RA   Barrell B.G., Parkhill J., Cole S.T.;
RT   "Genome plasticity of BCG and impact on vaccine efficacy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:5596-5601(2007).
CC   -!- FUNCTION: Catalyzes the methylation of the lipid moiety of the
CC       intermediate compounds phthiotriol and glycosylated phenolphthiotriol
CC       dimycoserosates to form phthiocerol dimycocerosates (DIM A) and
CC       glycosylated phenolphthiocerol dimycocerosates (PGL). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM408590; CAL72962.1; -; Genomic_DNA.
DR   RefSeq; WP_003414900.1; NC_008769.1.
DR   AlphaFoldDB; A1KMU6; -.
DR   SMR; A1KMU6; -.
DR   KEGG; mbb:BCG_2973; -.
DR   HOGENOM; CLU_068661_0_0_11; -.
DR   OMA; EWILRAH; -.
DR   Proteomes; UP000001472; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis; Lipid metabolism; Methyltransferase; Transferase.
FT   CHAIN           1..270
FT                   /note="Phthiotriol/phenolphthiotriol dimycocerosates
FT                   methyltransferase"
FT                   /id="PRO_0000305163"
SQ   SEQUENCE   270 AA;  30652 MW;  92116ADD4261EDE7 CRC64;
     MAFSRTHSLL ARAGSTSTYK RVWRYWYPLM TRGLGNDEIV FINWAYEEDP PMDLPLEASD
     EPNRAHINLY HRTATQVDLG GKQVLEVSCG HGGGASYLTR TLHPASYTGL DLNQAGIKLC
     KKRHRLPGLD FVRGDAENLP FDDESFDVVL NVEASHCYPH FRRFLAEVVR VLRPGGYFPY
     ADLRPNNEIA AWEADLAATP LRQLSQRQIN AEVLRGIGNN SQKSRDLVDR HLPAFLRFAG
     REFIGVQGTQ LSRYLEGGEL SYRMYCFTKD