ID   PHMT_MYCTA              Reviewed;         270 AA.
AC   A5U6W0;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MRA_2979;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- FUNCTION: Catalyzes the methylation of the lipid moiety of the
CC       intermediate compounds phthiotriol and glycosylated phenolphthiotriol
CC       dimycoserosates to form phthiocerol dimycocerosates (DIM A) and
CC       glycosylated phenolphthiocerol dimycocerosates (PGL). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC       Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase family.
CC       {ECO:0000305}.
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DR   EMBL; CP000611; ABQ74760.1; -; Genomic_DNA.
DR   RefSeq; WP_003414900.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U6W0; -.
DR   SMR; A5U6W0; -.
DR   STRING; 419947.MRA_2979; -.
DR   EnsemblBacteria; ABQ74760; ABQ74760; MRA_2979.
DR   KEGG; mra:MRA_2979; -.
DR   eggNOG; COG2226; Bacteria.
DR   HOGENOM; CLU_068661_0_0_11; -.
DR   OMA; EWILRAH; -.
DR   OrthoDB; 1664438at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR013216; Methyltransf_11.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF08241; Methyltransf_11; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis; Lipid metabolism; Methyltransferase; Transferase.
FT   CHAIN           1..270
FT                   /note="Phthiotriol/phenolphthiotriol dimycocerosates
FT                   methyltransferase"
FT                   /id="PRO_0000305166"
SQ   SEQUENCE   270 AA;  30652 MW;  92116ADD4261EDE7 CRC64;
     MAFSRTHSLL ARAGSTSTYK RVWRYWYPLM TRGLGNDEIV FINWAYEEDP PMDLPLEASD
     EPNRAHINLY HRTATQVDLG GKQVLEVSCG HGGGASYLTR TLHPASYTGL DLNQAGIKLC
     KKRHRLPGLD FVRGDAENLP FDDESFDVVL NVEASHCYPH FRRFLAEVVR VLRPGGYFPY
     ADLRPNNEIA AWEADLAATP LRQLSQRQIN AEVLRGIGNN SQKSRDLVDR HLPAFLRFAG
     REFIGVQGTQ LSRYLEGGEL SYRMYCFTKD