ID   PHNE_PENHR              Reviewed;         815 AA.
AC   A0A142C7A3;
DT   16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT   08-JUN-2016, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Putative transcription factor phnE {ECO:0000303|PubMed:26978228};
DE   AltName: Full=Phenalenone biosynthesis cluster protein E {ECO:0000303|PubMed:26978228};
GN   Name=phnE {ECO:0000303|PubMed:26978228};
OS   Penicillium herquei.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=69774;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND PATHWAY.
RC   STRAIN=ATCC 10118 / CBS 336.48 / NBRC 31747 / NRRL 1040;
RX   PubMed=26978228; DOI=10.1021/jacs.6b01528;
RA   Gao S.S., Duan A., Xu W., Yu P., Hang L., Houk K.N., Tang Y.;
RT   "Phenalenone polyketide cyclization catalyzed by fungal polyketide synthase
RT   and flavin-dependent monooxygenase.";
RL   J. Am. Chem. Soc. 138:4249-4259(2016).
CC   -!- FUNCTION: Putative transcription factor that may be involved in the
CC       regulation of the expression of the gene cluster that mediates the
CC       biosynthesis of phenalenones such as herqueinone, compounds that have
CC       been reported to treat tumors, bacterial infections and/or mycoses, and
CC       rheumatic diseases. {ECO:0000305|PubMed:26978228}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:26978228}.
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DR   EMBL; KU641630; AMP46755.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A142C7A3; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..815
FT                   /note="Putative transcription factor phnE"
FT                   /id="PRO_0000446166"
FT   REGION          522..577
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        523..549
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        563..577
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   815 AA;  90133 MW;  D6EFB8CBD41FC69F CRC64;
     MSGGAISIFG ELNAHTYLGK AFFSSINYKI HQWPECRRRL GRRLMGPAQA AGPGKSSVDE
     RNPNAAAATE INTNASIPLL QRECESFDEI QDRLTMMQDQ LSRLTATLDN KQNLVDRVDQ
     IGDKQSSMPT PPSTGHVVSD VDGQIQRYHG PWTLLAQCRQ LESDLASWSK ADHAAEVASL
     VTSMVQETMR VPSSSLSSFH TEIPGMGMCL PPRQLLSVMV ECFLKNADYA TSIFDHQSLY
     CAIDRVYRDP SNPEEKPWVL CFNLIILLTL GAEHSLQSED PFVRPMLQAV QTAAGNSRLL
     MEPRLVSVQA LALFSLFMQQ CYPDNEPLGD GIFAQACVLA RQMGLPQPHG YAATPSTLTA
     AEVDERHRVY QSLYIRNRYA TTTSGALMWL PNSIMCTGTA SAVGAHWELA KLQDEIHRVL
     GSCSFGSSDR RIKVAQLREK LRVWQEACLV AETQPMSMDR VILCLLFLGT RIYISMDNKE
     TDTESFLDDC RLSCLLLIVS CTKHLRPDFS NQFHHLLRRL NPSRRNSDGS AHSSPSSTPS
     SSSTSSPLPS PASERPPPLD VVTRPSTGTS TPSSPTLLPL PRLANAFPIT AIFILARHIL
     GISAEGKPIN THRTVTEINS DILLLESLLF CFQNNPPFLG GKDQTLHCSY KLGQVLDHLV
     RIVHTMTSDR TSPRAHASGL PLVTEHAEMT DYMSRMFMTS KGSPASDLTG LWYPRDVTSD
     TPMELSIPDF QSVWPTPQDS LASSTNPLAT AEGSIYTPAL HPTPIIPNTP LDLSELFGFT
     NSDASEVWNL GTETTDLLEN RRPSLKRQRT HFESQ