PHO13_ARATH
ID PHO13_ARATH Reviewed; 813 AA.
AC Q6R8G7; Q9LMF4; Q9XI83;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Phosphate transporter PHO1 homolog 3;
DE AltName: Full=Protein PHO1 homolog 3;
DE Short=AtPHO1;H3;
GN Name=PHO1;H3; OrderedLocusNames=At1g14040; ORFNames=F16A14.26, F7A19.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION, GENE FAMILY, AND
RP NOMENCLATURE.
RX PubMed=15122012; DOI=10.1104/pp.103.037945;
RA Wang Y., Ribot C., Rezzonico E., Poirier Y.;
RT "Structure and expression profile of the Arabidopsis PHO1 gene family
RT indicates a broad role in inorganic phosphate homeostasis.";
RL Plant Physiol. 135:400-411(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: May transport inorganic phosphate (Pi). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in vascular cylinder of roots, leaves and
CC filaments. Expressed in receptacle and stigma apex.
CC {ECO:0000269|PubMed:15122012}.
CC -!- INDUCTION: Not induced by Pi deficiency. {ECO:0000269|PubMed:15122012}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD39290.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAF79407.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY507955; AAR99485.1; -; mRNA.
DR EMBL; AC007576; AAD39290.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC068197; AAF79407.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29101.1; -; Genomic_DNA.
DR PIR; G86273; G86273.
DR RefSeq; NP_172857.2; NM_101270.3.
DR AlphaFoldDB; Q6R8G7; -.
DR SMR; Q6R8G7; -.
DR STRING; 3702.AT1G14040.1; -.
DR iPTMnet; Q6R8G7; -.
DR PaxDb; Q6R8G7; -.
DR PRIDE; Q6R8G7; -.
DR ProteomicsDB; 234907; -.
DR EnsemblPlants; AT1G14040.1; AT1G14040.1; AT1G14040.
DR GeneID; 837965; -.
DR Gramene; AT1G14040.1; AT1G14040.1; AT1G14040.
DR KEGG; ath:AT1G14040; -.
DR Araport; AT1G14040; -.
DR TAIR; locus:2014779; AT1G14040.
DR eggNOG; KOG1162; Eukaryota.
DR HOGENOM; CLU_006116_2_0_1; -.
DR InParanoid; Q6R8G7; -.
DR OMA; FRRYYDS; -.
DR OrthoDB; 536327at2759; -.
DR PhylomeDB; Q6R8G7; -.
DR PRO; PR:Q6R8G7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q6R8G7; baseline and differential.
DR Genevisible; Q6R8G7; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IDA:TAIR.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IBA:GO_Central.
DR GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0016036; P:cellular response to phosphate starvation; IBA:GO_Central.
DR GO; GO:0055062; P:phosphate ion homeostasis; IMP:TAIR.
DR GO; GO:0006817; P:phosphate ion transport; IBA:GO_Central.
DR GO; GO:0055069; P:zinc ion homeostasis; IEP:TAIR.
DR CDD; cd14476; SPX_PHO1_like; 1.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR034092; PHO1_SPX.
DR InterPro; IPR004331; SPX_dom.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 1.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Phosphate transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..813
FT /note="Phosphate transporter PHO1 homolog 3"
FT /id="PRO_0000398157"
FT TOPO_DOM 1..411
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 433..450
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 472..496
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 497..517
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 518..533
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 534..554
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 555..684
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 685..705
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 706..729
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 730..750
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 751..813
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 1..359
FT /note="SPX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00714"
FT DOMAIN 618..813
FT /note="EXS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00712"
FT REGION 214..266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 377
FT /note="E -> V (in Ref. 1; AAR99485)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 813 AA; 93837 MW; 065E03E01E62AD9B CRC64;
MKFGKEFSSQ MVPEWQQAYM DYDFLKTLLK EIITFKRRTN NAPSHGGAKT GGGLNRKLTL
YRAFSGLVST PRHKRSNSSH DVEEGVQLTG SMRSGPILVN TTASHGYETT FLMAAEEGGE
YELVFFRRLD DEFNKVDKFY RKKVEEVLKE AAMLNKQMDA LIAFRVKVEN PDGWRWEERT
VEMTRLASDI ATSAAALSAS TPAGAKSMKV RSQEHMEAIQ EGGSSRAGLM EDDEEDEDEQ
NETSVVSTGA IDNETTTSRM RGARPSPIDV LGRVKINNTK ETPRSTIKGV LKVSKQTDLK
FSRENLMKVE ESLKRAFIEF YQKLRLLKSY SFLNVLAFSK ILKKYDKITS RDATKPYMKV
VDSSYLGSSD EVMRLMERVE ATFIKHFANA NRAKAMNILR PKAKRERHRI TFSTGFSAGC
VFSLIVALVA IIRTRNLLEM EGQKEYMNTM FPLYSLFGFI VLHIIVYAAN IYYWRRYRVN
YSFIFGFKQG TELGYRQVLL VGFSIGVLAL LCVLANLDME ADPKTKAYQA RTEILPLILL
AAMFIVLVLP FNYFYRSSRF FFLTCLFHCL AAPLYKVTLP DFFLGDQLTS QVQAIRSIEF
YICYYGWGDF RHRKSTCKES DVYNTFFFIV AVIPYVSRLL QCLRRLFEEK NPEQGYNGLK
YFLTIVAVCL RTAYSIQKGQ VAWRVLAAVF SFIAAIFCTY WDFVHDWGLL NRTSKNRWLR
DKLLVPQKKV YFIAMVLNVL LRFAWIQTVL DFNFSFMHRQ TMVAIVASLE IIRRGIWNFF
RLENEHLNNV GKYRAFKSVP LPFNYDEDDD KDN
