PHO14_ARATH
ID PHO14_ARATH Reviewed; 745 AA.
AC Q6R8G6; Q9STK3;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Phosphate transporter PHO1 homolog 4;
DE AltName: Full=Protein PHO1 homolog 4;
DE Short=AtPHO1;H4;
GN Name=PHO1-H4; OrderedLocusNames=At4g25350; ORFNames=T30C3.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION, GENE FAMILY, AND
RP NOMENCLATURE.
RX PubMed=15122012; DOI=10.1104/pp.103.037945;
RA Wang Y., Ribot C., Rezzonico E., Poirier Y.;
RT "Structure and expression profile of the Arabidopsis PHO1 gene family
RT indicates a broad role in inorganic phosphate homeostasis.";
RL Plant Physiol. 135:400-411(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: May transport inorganic phosphate (Pi). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in root epidermis and cortex, leaf
CC hydathodes, pollen grains and stigma apex.
CC {ECO:0000269|PubMed:15122012}.
CC -!- INDUCTION: Not induced by Pi deficiency. {ECO:0000269|PubMed:15122012}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB45511.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB81346.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY507956; AAR99486.1; -; mRNA.
DR EMBL; AL079350; CAB45511.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161563; CAB81346.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85045.1; -; Genomic_DNA.
DR PIR; T10214; T10214.
DR RefSeq; NP_194265.2; NM_118667.3.
DR AlphaFoldDB; Q6R8G6; -.
DR STRING; 3702.AT4G25350.1; -.
DR PaxDb; Q6R8G6; -.
DR PRIDE; Q6R8G6; -.
DR ProteomicsDB; 235060; -.
DR EnsemblPlants; AT4G25350.1; AT4G25350.1; AT4G25350.
DR GeneID; 828638; -.
DR Gramene; AT4G25350.1; AT4G25350.1; AT4G25350.
DR KEGG; ath:AT4G25350; -.
DR Araport; AT4G25350; -.
DR TAIR; locus:2138038; AT4G25350.
DR eggNOG; KOG1162; Eukaryota.
DR HOGENOM; CLU_006116_2_0_1; -.
DR InParanoid; Q6R8G6; -.
DR OMA; AVTHAGY; -.
DR OrthoDB; 536327at2759; -.
DR PhylomeDB; Q6R8G6; -.
DR PRO; PR:Q6R8G6; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q6R8G6; baseline and differential.
DR Genevisible; Q6R8G6; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IBA:GO_Central.
DR GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0016036; P:cellular response to phosphate starvation; IBA:GO_Central.
DR GO; GO:0009960; P:endosperm development; IMP:TAIR.
DR GO; GO:0006817; P:phosphate ion transport; IBA:GO_Central.
DR GO; GO:0045793; P:positive regulation of cell size; IMP:TAIR.
DR GO; GO:0010017; P:red or far-red light signaling pathway; IMP:TAIR.
DR GO; GO:0010468; P:regulation of gene expression; IMP:TAIR.
DR GO; GO:0080050; P:regulation of seed development; IMP:TAIR.
DR GO; GO:0080113; P:regulation of seed growth; IMP:TAIR.
DR CDD; cd14476; SPX_PHO1_like; 1.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR034092; PHO1_SPX.
DR InterPro; IPR004331; SPX_dom.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 1.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Phosphate transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..745
FT /note="Phosphate transporter PHO1 homolog 4"
FT /id="PRO_0000398158"
FT TOPO_DOM 1..342
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 364..383
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 405..427
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 449..464
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 465..485
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 486..615
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 616..636
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 637..660
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 661..681
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 682..745
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 1..290
FT /note="SPX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00714"
FT DOMAIN 550..744
FT /note="EXS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00712"
SQ SEQUENCE 745 AA; 86986 MW; F616896A4FCDECE9 CRC64;
MRFGKEFVSQ MIPEWQEAYI DYAYLKTILQ DIQASRNRSD SNNQSSTPSF ARNLTRRYNR
DALVSENHDI VVNTVTRLEE GLETAAYETT FLKAGEAGGD FEVTFFRTLD REFNKVNNFY
RLKVETARTE ALALNKQMDA LIAFRHKVMD QNQKNPSVFD SVSEDINGSA SEVGSSSKCT
EHNVALADLM RNEDTSNESI LERIRMNKTR EITPLSAIKT ILKVHKQDEL KFTRDNLKEV
EKRLQVAFIE FYQKLRHLKN YSFLNASAVS KIMKKYDKIA KRNAAKLYME MVDKSFLSSS
EEVHKLLLKV ESIFIEHFSN SNRREGMSHL RPKINKERHL ITFSTGFFFG CGISLIVALG
LIIHARNIMG TPGQRTYMET MFPLYRFFGF VVLHMDVYAA NIYFWRRYRV NYSFIFGFKQ
GTELGYRHVL LLSFGLGTLS LCAVLLNLDM EMDAQTKDYR LVTELIPLFL LVLVIIIVLC
PFNILYRSSR FFFLSVLFRC IAAPFYAVHL PDFFLGDQLT SQVQALRSLE FYICYYGFGD
FRYRRRNTCT SNIGFRTFYF IVAVIPYWLR FLQCIRRMVE DRDLSHGYNG IKYLLTIVAA
SLRTAYTLNR GSNWNITAWV FSGVATFYGT YWDIVLDWGL LQRGCKNSFL RDKLLVPHKT
VYYAAMVLNV LLRLVWLQTV LDLKFSFLHR ETMVALMACL EIIRRGIWNF FRLENEHLNN
VGRYRAFKTV PLPFNYEEDG DHHNN
