PHO16_ARATH
ID PHO16_ARATH Reviewed; 756 AA.
AC Q6R8G4; O81049;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Phosphate transporter PHO1 homolog 6;
DE AltName: Full=Protein PHO1 homolog 6;
DE Short=AtPHO1;H6;
GN Name=PHO1-H6; OrderedLocusNames=At2g03250; ORFNames=T18E12.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION, GENE FAMILY, AND
RP NOMENCLATURE.
RX PubMed=15122012; DOI=10.1104/pp.103.037945;
RA Wang Y., Ribot C., Rezzonico E., Poirier Y.;
RT "Structure and expression profile of the Arabidopsis PHO1 gene family
RT indicates a broad role in inorganic phosphate homeostasis.";
RL Plant Physiol. 135:400-411(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: May transport inorganic phosphate (Pi). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in anther connective tissue.
CC {ECO:0000269|PubMed:15122012}.
CC -!- INDUCTION: Not induced by Pi deficiency. {ECO:0000269|PubMed:15122012}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC34477.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY507958; AAR99488.1; -; mRNA.
DR EMBL; AC005313; AAC34477.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; T02701; T02701.
DR AlphaFoldDB; Q6R8G4; -.
DR STRING; 3702.AT2G03250.1; -.
DR PaxDb; Q6R8G4; -.
DR PeptideAtlas; Q6R8G4; -.
DR PRIDE; Q6R8G4; -.
DR Araport; AT2G03250; -.
DR TAIR; locus:2056926; AT2G03250.
DR eggNOG; KOG1162; Eukaryota.
DR HOGENOM; CLU_006116_2_0_1; -.
DR InParanoid; Q6R8G4; -.
DR PhylomeDB; Q6R8G4; -.
DR PRO; PR:Q6R8G4; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q6R8G4; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IBA:GO_Central.
DR GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0016036; P:cellular response to phosphate starvation; IBA:GO_Central.
DR GO; GO:0006817; P:phosphate ion transport; IBA:GO_Central.
DR CDD; cd14476; SPX_PHO1_like; 1.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR034092; PHO1_SPX.
DR InterPro; IPR004331; SPX_dom.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 2.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Phosphate transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..756
FT /note="Phosphate transporter PHO1 homolog 6"
FT /id="PRO_0000398160"
FT TOPO_DOM 1..355
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 377..396
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 418..440
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 462..477
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 478..498
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 499..631
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 632..652
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 653..676
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 677..697
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 698..756
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 1..303
FT /note="SPX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00714"
FT DOMAIN 562..756
FT /note="EXS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00712"
SQ SEQUENCE 756 AA; 87852 MW; 993BBAFB8CA7E368 CRC64;
MKFGKDFSSE WQQAYVDYKY LKTLVKDINR FKRKTNLHGG QISLSSTVLE IEDGITTATI
QVSSTASQRY ETTFLMTAEK GGEYELVFFR RLDDEFNKVE KFYREKVDEV VKEAAVLNKQ
MDALIAFRLK MKEESTVEMA RFALHGVVSP AELAKNPSMK VHMEAIEEGG SSRAGRRSDE
DDYYTDEEDH NDVFFTPANN LSKMKSSSSA FIEVLDSIKI NNTKEALQSN TKSVLKVSNH
TELKFSRDNL RKIEEKLICA FVEFHRKLWY LKSYSFLNVL ALSKILTKYD KITSRDAAKS
YMKMVDKSCL GSSDEVMKLM ENVEATFIKQ FTNGNRTKGM NILRPKPKRE RHRLTFSTGF
LGGCMFSLIV ALVAIVRTRN ILQDDGQKQY MNTMFPLYSL FGFIMLHMTM YAANIYFWRQ
YRVNYSFIFG FKQGTELGYK QVLFVGFSIG ALALLCVLAN LDMETDPKTK DYQALTELLP
LFLLIAMFVV LVVPFNIFYR SSRFFFLTTL FHMLAAPLYK VTLPDFFLAD QLCSQAQTLR
SIEFYICYYG WGDFKQRKNT CKDSQVFNTF LFIVSAFPFF SRFLQCMRRM LEEKNIEQGY
NGFKYIVIVV AVCLGMAYEV DDEKDRQIIW RLLGGITSAM AVVFCTYWDL VYDWGLLNRT
SKNPWLRDNL LIPHKEVYVL AMILNVVLRF AWMQTVLDFK FESIHTQTVV AVVASLEIIR
RGIWNFFRLE NEHLNNVGKY RAFKAVSLPF NYEVDH
