ID   PHOB_HAEIN              Reviewed;         231 AA.
AC   P45189;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Phosphate regulon transcriptional regulatory protein PhoB;
GN   Name=phoB; OrderedLocusNames=HI_1379;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: This protein is a positive regulator for the phosphate
CC       regulon. Transcription of this operon is positively regulated by PhoB
CC       and PhoR when phosphate is limited (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- PTM: Phosphorylated by PhoR. {ECO:0000250}.
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DR   EMBL; L42023; AAC23025.1; -; Genomic_DNA.
DR   PIR; F64120; F64120.
DR   RefSeq; NP_439531.1; NC_000907.1.
DR   RefSeq; WP_005650606.1; NC_000907.1.
DR   AlphaFoldDB; P45189; -.
DR   SMR; P45189; -.
DR   STRING; 71421.HI_1379; -.
DR   EnsemblBacteria; AAC23025; AAC23025; HI_1379.
DR   KEGG; hin:HI_1379; -.
DR   PATRIC; fig|71421.8.peg.1434; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_4_6; -.
DR   OMA; IDRVWGS; -.
DR   PhylomeDB; P45189; -.
DR   BioCyc; HINF71421:G1GJ1-1405-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IBA:GO_Central.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR011879; Sig_transdc_resp-reg_PhoB.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   TIGRFAMs; TIGR02154; PhoB; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphate transport; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation; Transport;
KW   Two-component regulatory system.
FT   CHAIN           1..231
FT                   /note="Phosphate regulon transcriptional regulatory protein
FT                   PhoB"
FT                   /id="PRO_0000081188"
FT   DOMAIN          4..119
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        127..225
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         52
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   231 AA;  27508 MW;  B90BF5FDD6BF414B CRC64;
     MTRKILIVED ECAIREMIAL FLSQKYYDVI EASDFKTAIN KIKENPKLIL LDWMLPGRSG
     IQFIQYIKKQ ESYAAIPIIM LTAKSTEEDC IACLNAGADD YITKPFSPQI LLARIEAVWR
     RIYEQQSQFI QIDELSIDEN AQRVFFQQQE INLSSTEFKL LHFFMRHPEK VYSREQLLNR
     IWHNDLEVEY RTVDSYIRRL RRNLAPFQCE HYIQTVRGSG YRFSSYLRDK Q