PHOB_KLEPN
ID PHOB_KLEPN Reviewed; 229 AA.
AC P45605;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=Phosphate regulon transcriptional regulatory protein PhoB;
GN Name=phoB;
OS Klebsiella pneumoniae.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=573;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2556368; DOI=10.1128/jb.171.12.6593-6599.1989;
RA Lee T.Y., Makino K., Shinagawa H., Amemura M., Nakata A.;
RT "Phosphate regulon in members of the family Enterobacteriaceae: comparison
RT of the phoB-phoR operons of Escherichia coli, Shigella dysenteriae, and
RT Klebsiella pneumoniae.";
RL J. Bacteriol. 171:6593-6599(1989).
CC -!- FUNCTION: This protein is a positive regulator for the phosphate
CC regulon. Transcription of this operon is positively regulated by PhoB
CC and PhoR when phosphate is limited.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- PTM: Phosphorylated by PhoR. {ECO:0000250}.
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DR EMBL; M31794; AAA25122.1; -; Genomic_DNA.
DR PIR; C44753; C44753.
DR RefSeq; WP_002890343.1; NZ_WYAM01000013.1.
DR AlphaFoldDB; P45605; -.
DR SMR; P45605; -.
DR GeneID; 61331490; -.
DR OMA; IDRVWGS; -.
DR OrthoDB; 817710at2; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR011879; Sig_transdc_resp-reg_PhoB.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR TIGRFAMs; TIGR02154; PhoB; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Cytoplasm; DNA-binding; Phosphate transport; Phosphoprotein;
KW Transcription; Transcription regulation; Transport;
KW Two-component regulatory system.
FT CHAIN 1..229
FT /note="Phosphate regulon transcriptional regulatory protein
FT PhoB"
FT /id="PRO_0000081189"
FT DOMAIN 4..120
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 129..227
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 53
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 229 AA; 26379 MW; 4D30374C8826FBA3 CRC64;
MARRILVVED EAPIREMVCF VLEQNGFQPV EAEDYDSAVN QLNEPWPDLI LLDWMLPGGS
GLQFIKLLKR EAMTRDIPVV MLTARGEEED RVRGLETGAD DYITKPFSPK ELVARIKAVM
RRISPMAVEE VIEMQGLSLD PSSHRVMTGD SPLDMGPTEF KLLHFFMTHP ERVYSREQLL
NHVWGTNVYV EDRTVDVHIR RLRKALEHSG HDRMVQTVRG TGYRFSARF