ID   PHOB_SHIDY              Reviewed;         229 AA.
AC   P45606;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Phosphate regulon transcriptional regulatory protein PhoB;
GN   Name=phoB;
OS   Shigella dysenteriae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=622;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2556368; DOI=10.1128/jb.171.12.6593-6599.1989;
RA   Lee T.Y., Makino K., Shinagawa H., Amemura M., Nakata A.;
RT   "Phosphate regulon in members of the family Enterobacteriaceae: comparison
RT   of the phoB-phoR operons of Escherichia coli, Shigella dysenteriae, and
RT   Klebsiella pneumoniae.";
RL   J. Bacteriol. 171:6593-6599(1989).
CC   -!- FUNCTION: This protein is a positive regulator for the phosphate
CC       regulon. Transcription of this operon is positively regulated by PhoB
CC       and PhoR when phosphate is limited.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- PTM: Phosphorylated by PhoR. {ECO:0000250}.
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DR   EMBL; M31793; AAA26535.1; -; Genomic_DNA.
DR   PIR; A44753; A44753.
DR   RefSeq; WP_000113934.1; NZ_UAUQ01000003.1.
DR   AlphaFoldDB; P45606; -.
DR   BMRB; P45606; -.
DR   SMR; P45606; -.
DR   OMA; IDRVWGS; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR011879; Sig_transdc_resp-reg_PhoB.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   TIGRFAMs; TIGR02154; PhoB; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphate transport; Phosphoprotein;
KW   Transcription; Transcription regulation; Transport;
KW   Two-component regulatory system.
FT   CHAIN           1..229
FT                   /note="Phosphate regulon transcriptional regulatory protein
FT                   PhoB"
FT                   /id="PRO_0000081192"
FT   DOMAIN          4..120
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        129..227
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         53
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   229 AA;  26463 MW;  EB5DA09984059D93 CRC64;
     MARRILVVED EAPIREMVCF VLEQNGFQPV EAEDYDSAVN QLNEPWPDLI LLDWMLPGGS
     GIQFIKHLKR ESMTRDIPVV MLTARGEEED RVRGLETGAD DYITKPFSPK ELVARIKAVM
     RRISPMAVEE VIEMQGLSLD PTSHRVMTGE EPLEMGPTEF KLLHFFMTHP ERVYSREQLL
     NHVWGTNVYV EDRTVDVHIR RLRKALEPGG HDRMVQTVRG TGYRFSTRF