PHOCN_PONAB
ID PHOCN_PONAB Reviewed; 225 AA.
AC Q5RDB1; Q5R8K8;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=MOB-like protein phocein;
DE AltName: Full=Mob1 homolog 3;
DE Short=Mob3;
DE AltName: Full=Mps one binder kinase activator-like 3;
DE AltName: Full=Preimplantation protein 3;
GN Name=MOB4; Synonyms=MOB3, MOBKL3, PHOCN, PREI3;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Heart;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in membrane trafficking, specifically in
CC membrane budding reactions. {ECO:0000250}.
CC -!- SUBUNIT: Binds STRN, STRN3 and STRN4. Part of a ternary complex
CC containing MOB4/PHOCN, STRN and/or STRN3 and PPA2. Interacts with DNM1
CC and EPS15. Interacts with nucleoside diphosphate kinase (By
CC similarity). Interacts with CTTNBP2 and CTTNBP2NL (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Membrane;
CC Peripheral membrane protein. Golgi apparatus, Golgi stack membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5RDB1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5RDB1-2; Sequence=VSP_020022;
CC -!- PTM: Phosphorylated on serine residues. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MOB1/phocein family. {ECO:0000305}.
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DR EMBL; CR858003; CAH90246.1; -; mRNA.
DR EMBL; CR859744; CAH91902.1; -; mRNA.
DR RefSeq; NP_001127258.1; NM_001133786.1.
DR RefSeq; NP_001128839.1; NM_001135367.1.
DR RefSeq; XP_009236204.1; XM_009237929.1. [Q5RDB1-2]
DR AlphaFoldDB; Q5RDB1; -.
DR SMR; Q5RDB1; -.
DR STRING; 9601.ENSPPYP00000014578; -.
DR Ensembl; ENSPPYT00000015167; ENSPPYP00000014578; ENSPPYG00000013047. [Q5RDB1-2]
DR GeneID; 100174313; -.
DR GeneID; 100189755; -.
DR KEGG; pon:100174313; -.
DR CTD; 25843; -.
DR eggNOG; KOG1852; Eukaryota.
DR GeneTree; ENSGT01050000244956; -.
DR HOGENOM; CLU_056981_3_0_1; -.
DR InParanoid; Q5RDB1; -.
DR OMA; CKRFTTY; -.
DR OrthoDB; 1229701at2759; -.
DR TreeFam; TF314078; -.
DR Proteomes; UP000001595; Chromosome 2B.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019900; F:kinase binding; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.140.30; -; 1.
DR InterPro; IPR005301; MOB_kinase_act_fam.
DR InterPro; IPR036703; MOB_kinase_act_sf.
DR PANTHER; PTHR22599; PTHR22599; 1.
DR Pfam; PF03637; Mob1_phocein; 1.
DR SMART; SM01388; Mob1_phocein; 1.
DR SUPFAM; SSF101152; SSF101152; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Golgi apparatus; Membrane; Metal-binding;
KW Phosphoprotein; Reference proteome; Transport; Zinc.
FT CHAIN 1..225
FT /note="MOB-like protein phocein"
FT /id="PRO_0000247606"
FT BINDING 92
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 97
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 169
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT BINDING 174
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250"
FT VAR_SEQ 20..40
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_020022"
FT CONFLICT 9
FT /note="V -> L (in Ref. 1; CAH90246)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="N -> D (in Ref. 1; CAH91902)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 225 AA; 26032 MW; D0EF1219711458BA CRC64;
MVMAEGTAVL RRNRPGTKAQ DFYNWPDESF DEMDSTLAVQ QYIQQNIRAD CSNIDKILEP
PEGQDEGVWK YEHLRQFCLE LNGLAVKLQS ECHPDTCTQM TATEQWIFLC AAHKTPKECP
AIDYTRHTLD GAACLLNSNK YFPSRVSIKE SSVAKLGSVC RRIYRIFSHA YFHHRQIFDE
YENETFLCHR FTKFVMKYNL MSKDNLIVPI LEEEVQNSVS GESEA
