ID   PHOE_KLEPN              Reviewed;         351 AA.
AC   P30704;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Outer membrane porin PhoE;
DE   AltName: Full=Outer membrane pore protein E;
DE   Flags: Precursor;
GN   Name=phoE;
OS   Klebsiella pneumoniae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3032618; DOI=10.1111/j.1432-1033.1987.tb11080.x;
RA   van der Ley P., Bekkers A., van Meersbergen J., Tommassen J.;
RT   "A comparative study on the phoE genes of three enterobacterial species.
RT   Implications for structure-function relationships in a pore-forming protein
RT   of the outer membrane.";
RL   Eur. J. Biochem. 164:469-475(1987).
CC   -!- FUNCTION: Uptake of inorganic phosphate, phosphorylated compounds, and
CC       some other negatively charged solutes.
CC   -!- SUBUNIT: Homotrimer.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Multi-pass membrane protein.
CC   -!- INDUCTION: By phosphate starvation.
CC   -!- SIMILARITY: Belongs to the Gram-negative porin family. {ECO:0000305}.
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DR   EMBL; M28295; AAA25121.1; -; Genomic_DNA.
DR   AlphaFoldDB; P30704; -.
DR   SMR; P30704; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:InterPro.
DR   CDD; cd00342; gram_neg_porins; 1.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR033900; Gram_neg_porin_domain.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   InterPro; IPR001897; Porin_gammaproteobac.
DR   InterPro; IPR001702; Porin_Gram-ve.
DR   InterPro; IPR013793; Porin_Gram-ve_CS.
DR   Pfam; PF00267; Porin_1; 1.
DR   PRINTS; PR00183; ECOLIPORIN.
DR   PRINTS; PR00182; ECOLNEIPORIN.
DR   PROSITE; PS00576; GRAM_NEG_PORIN; 1.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Ion transport; Membrane; Porin; Signal;
KW   Stress response; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..351
FT                   /note="Outer membrane porin PhoE"
FT                   /id="PRO_0000025245"
SQ   SEQUENCE   351 AA;  38894 MW;  86A5286C12502EC7 CRC64;
     MKKSTLALMM MGFVASTATQ AAEVYNKNAN KLDVYGKIKA MHYFSDYDSK DGDQTYVRFG
     IKGETQINED LTGYGRWESE FSGNKTESDS SQQKTRLAFA GVKLKNYGSF DYGRNLGALY
     DVEAWTDMFP EFGGDSSAQT DNFMTKRASG LATYRNTDFF GLVDGLDLTL QYQGKNEGRE
     AKKQNGDGVG TSLSYDFGGT DFAVSAAYTS SDRTNDQNLL ARAQGSKAEA WATGLKYDAN
     NIYLATMYSE TRKMTPISGG FANKAQNFEA VAQYQFDFGL RPSLGYVLSK GKDIEGVGSE
     DLVNYIDVGL TYYFNKNMNA FVDYKINQLK SDNKLGINDD DIVALGMTYQ F