PHOG_EMENI
ID PHOG_EMENI Reviewed; 566 AA.
AC Q05534; C8VM27; Q5BDG6;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 3.
DT 25-MAY-2022, entry version 117.
DE RecName: Full=Protein pacG;
DE AltName: Full=Nonrepressible acid phosphatase regulator pacG;
GN Name=pacG; ORFNames=AN1414;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-461.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=7916713; DOI=10.1016/0378-1119(93)90426-4;
RA Macrae W.D., Buxton F.P., Sibley S., Garven S., Gwynne D.I., Arst H.N. Jr.,
RA Davies R.W.;
RT "Characterization of an Aspergillus nidulans genomic DNA fragment
RT conferring phosphate-non-repressible acid-phosphatase activity.";
RL Gene 130:247-251(1993).
CC -!- FUNCTION: Transcription factor that acts as a positive regulator of
CC nonrepressible acid phosphatase activity. Is a major regulator of
CC responses to nitrogen and carbon starvation and is essential for the
CC expression of genes involved in vegetative incompatibility (like pin-c,
CC het-6, and tol). Vegetative incompatibility is a non-self-recognition
CC system ubiquitous in filamentous fungi which results in programmed cell
CC death (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}.
CC -!- CAUTION: Was originally thought to be a phosphatase.
CC {ECO:0000305|PubMed:7916713}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CBF84810.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAA64544.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AACD01000022; EAA64544.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BN001307; CBF84810.1; ALT_SEQ; Genomic_DNA.
DR EMBL; M96993; AAA33289.1; -; Genomic_DNA.
DR PIR; JN0783; JN0783.
DR RefSeq; XP_659018.1; XM_653926.1.
DR AlphaFoldDB; Q05534; -.
DR STRING; 227321.Q05534; -.
DR PRIDE; Q05534; -.
DR EnsemblFungi; EAA64544; EAA64544; AN1414.2.
DR GeneID; 2875501; -.
DR KEGG; ani:AN1414.2; -.
DR eggNOG; ENOG502SAHY; Eukaryota.
DR HOGENOM; CLU_789952_0_0_1; -.
DR InParanoid; Q05534; -.
DR OrthoDB; 1021134at2759; -.
DR Proteomes; UP000000560; Chromosome VII.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000228; C:nuclear chromosome; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 2.60.40.1390; -; 1.
DR InterPro; IPR024061; NDT80_DNA-bd_dom.
DR InterPro; IPR037141; NDT80_DNA-bd_dom_sf.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR Pfam; PF05224; NDT80_PhoG; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS51517; NDT80; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..566
FT /note="Protein pacG"
FT /id="PRO_0000023977"
FT DNA_BIND 79..326
FT /note="NDT80"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00850"
FT REGION 314..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 376
FT /note="G -> R (in Ref. 3; AAA33289)"
FT /evidence="ECO:0000305"
FT CONFLICT 423
FT /note="R -> L (in Ref. 3; AAA33289)"
FT /evidence="ECO:0000305"
FT CONFLICT 447
FT /note="G -> C (in Ref. 3; AAA33289)"
FT /evidence="ECO:0000305"
FT CONFLICT 451
FT /note="P -> S (in Ref. 3; AAA33289)"
FT /evidence="ECO:0000305"
FT CONFLICT 460..461
FT /note="AS -> VV (in Ref. 3; AAA33289)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 566 AA; 61871 MW; 9BC5AB22BCDC665E CRC64;
MEGFDTMALP YLASPLSLGN MQGTDYLNAL QGMDLPDQRS NFDSETFVSG DDLTFAHLSP
QTLKRFSSGY EDSFPEMVTS FDPPPPAEPP ADSSIDHNNK LLSFSMPVYP WTLLDYSFRR
ASISISAQLH GMFFLAESPW TTSPTENAPP QQGAELTCYR RNLFQITGSV TLPRALRYII
TDTGDRIPIV AHELTVSATE SVEGNSVKII SVPWKTPAAN DAGKDTGNSS NTAAKVEKEP
PAIPLDMLTG QDLDADYATF PIAWKRLQFR VATANNGRRK ELQQHFVVRL RVVATLSTGM
KTPICEVHSG PVIVRGRSPR NFQSRKDLPL SGSAAASRKN AQAAAASNNL TRTSPSLTDK
AKTVVKSSSP ETSSNGVPQQ SPPNWALATN STLPPPTTTT LPHSSVYSQS SPEFSRPVEA
HRRTTSAIAA PINLSLLDDD SLNLSNGDSR PHTSFSNDLA SKSLSVDSGR PVKMRKVSHS
MPQAQSRSTS ATFLNTANFQ QMLPVPFTSE SADVLYEYFP LGLEDWQGPV DAVYRPHVVH
HTNMPQMKYI TARGQSKRYF AAEDVF
