ID   PHOL_MYCTU              Reviewed;         352 AA.
AC   P9WIA3; L0TCB4; O05830; P0A5S0;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=PhoH-like protein;
GN   OrderedLocusNames=Rv2368c; ORFNames=MTCY27.12;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PhoH family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45156.1; -; Genomic_DNA.
DR   PIR; G70586; G70586.
DR   RefSeq; WP_003412235.1; NZ_NVQJ01000029.1.
DR   RefSeq; YP_177874.1; NC_000962.3.
DR   AlphaFoldDB; P9WIA3; -.
DR   SMR; P9WIA3; -.
DR   STRING; 83332.Rv2368c; -.
DR   PaxDb; P9WIA3; -.
DR   GeneID; 45426355; -.
DR   GeneID; 885998; -.
DR   KEGG; mtu:Rv2368c; -.
DR   TubercuList; Rv2368c; -.
DR   eggNOG; COG1702; Bacteria.
DR   OMA; PAQMKMV; -.
DR   PhylomeDB; P9WIA3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR004087; KH_dom.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003714; PhoH.
DR   Pfam; PF02562; PhoH; 1.
DR   SMART; SM00322; KH; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Cytoplasm; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..352
FT                   /note="PhoH-like protein"
FT                   /id="PRO_0000201158"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         150..157
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   352 AA;  37799 MW;  D34FF896A7678298 CRC64;
     MTSRETRAAD AAGARQADAQ VRSSIDVPPD LVVGLLGSAD ENLRALERTL SADLHVRGNA
     VTLCGEPADV ALAERVISEL IAIVASGQSL TPEVVRHSVA MLVGTGNESP AEVLTLDILS
     RRGKTIRPKT LNQKRYVDAI DANTIVFGIG PAGTGKTYLA MAKAVHALQT KQVTRIILTR
     PAVEAGERLG FLPGTLSEKI DPYLRPLYDA LYDMMDPELI PKLMSAGVIE VAPLAYMRGR
     TLNDAFIVLD EAQNTTAEQM KMFLTRLGFG SKVVVTGDVT QIDLPGGARS GLRAAVDILE
     DIDDIHIAEL TSVDVVRHRL VSEIVDAYAR YEEPGSGLNR AARRASGARG RR