ID   PHOP2_XENTR             Reviewed;         238 AA.
AC   Q66KD6;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Probable phosphatase phospho2;
DE            EC=3.1.3.- {ECO:0000250|UniProtKB:Q8TCD6};
GN   Name=phospho2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable phosphatase. {ECO:0000250|UniProtKB:Q8TCD6}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:Q8TCT1};
CC   -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. PHOSPHO
CC       family. {ECO:0000305}.
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DR   EMBL; BC080449; AAH80449.1; -; mRNA.
DR   RefSeq; NP_001007942.1; NM_001007941.2.
DR   RefSeq; XP_012825780.1; XM_012970326.2.
DR   RefSeq; XP_012825781.1; XM_012970327.2.
DR   AlphaFoldDB; Q66KD6; -.
DR   SMR; Q66KD6; -.
DR   STRING; 8364.ENSXETP00000040976; -.
DR   PaxDb; Q66KD6; -.
DR   DNASU; 493318; -.
DR   Ensembl; ENSXETT00000040976; ENSXETP00000040976; ENSXETG00000018895.
DR   GeneID; 493318; -.
DR   KEGG; xtr:493318; -.
DR   CTD; 493911; -.
DR   Xenbase; XB-GENE-1002120; phospho2.
DR   eggNOG; KOG3120; Eukaryota.
DR   HOGENOM; CLU_068983_0_1_1; -.
DR   InParanoid; Q66KD6; -.
DR   OMA; ICCEELA; -.
DR   OrthoDB; 1454608at2759; -.
DR   PhylomeDB; Q66KD6; -.
DR   TreeFam; TF300112; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000018895; Expressed in egg cell and 17 other tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006384; HAD_hydro_PyrdxlP_Pase-like.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR016965; Pase_PHOSPHO-typ.
DR   PANTHER; PTHR20889; PTHR20889; 1.
DR   Pfam; PF06888; Put_Phosphatase; 1.
DR   PIRSF; PIRSF031051; PyrdxlP_Pase_PHOSPHO2; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01489; DKMTPPase-SF; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Magnesium; Metal-binding; Reference proteome.
FT   CHAIN           1..238
FT                   /note="Probable phosphatase phospho2"
FT                   /id="PRO_0000068836"
FT   ACT_SITE        8
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TCT1"
FT   ACT_SITE        10
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GD0"
FT   BINDING         8
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GD0"
FT   BINDING         10
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GD0"
FT   BINDING         19
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TCT1"
FT   BINDING         99
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TCT1"
FT   BINDING         179
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000250|UniProtKB:Q96GD0"
SQ   SEQUENCE   238 AA;  26785 MW;  D4798B807ED381B5 CRC64;
     MKTLLVFDFD HTIINDNSDT WIVQCVPGKK LPNGLQNSYE KGKWTEYMGR VFSYLGEQGI
     REEDMKRIMI AIPYTPGMTD LLHFIGQNKD SFDCIIISDS NTIFIDWILT HANVHNVFDK
     VFTNPAAFDS VGNLTVQNFH VHHCTTCPTN LCKKKVLEEF VAKQSSNSAH YSKIVYVGDG
     GNDLCPVTFL KKGDIAMPRA GYTLDKHIAK DVTLVDSTIS VWSTGAEILS HLKLLLEH