ID   PHOP_SALTI              Reviewed;         224 AA.
AC   Q8Z7H2; Q7C9E6;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Virulence transcriptional regulatory protein PhoP;
GN   Name=phoP; OrderedLocusNames=STY1271, t1689;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
RN   [3]
RP   FUNCTION.
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=10084994; DOI=10.1128/iai.67.4.1614-1622.1999;
RA   van Velkinburgh J.C., Gunn J.S.;
RT   "PhoP-PhoQ-regulated loci are required for enhanced bile resistance in
RT   Salmonella spp.";
RL   Infect. Immun. 67:1614-1622(1999).
RN   [4]
RP   FUNCTION.
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=10075419; DOI=10.1099/13500872-145-2-367;
RA   Baker S.J., Gunn J.S., Morona R.;
RT   "The Salmonella typhi melittin resistance gene pqaB affects intracellular
RT   growth in PMA-differentiated U937 cells, polymyxin B resistance and
RT   lipopolysaccharide.";
RL   Microbiology 145:367-378(1999).
CC   -!- FUNCTION: Member of the two-component regulatory system PhoQ/PhoP which
CC       regulates the expression of genes involved in virulence and resistance
CC       to host defense antimicrobial peptides. Promotes intramacrophage
CC       survival of S.typhi. Is required to enhance bacterial resistance to
CC       bile in the human intestinal cells. {ECO:0000269|PubMed:10075419,
CC       ECO:0000269|PubMed:10084994}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by PhoQ. {ECO:0000305}.
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DR   EMBL; AL513382; CAD08355.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO69314.1; -; Genomic_DNA.
DR   RefSeq; NP_455723.1; NC_003198.1.
DR   RefSeq; WP_000986523.1; NZ_FFOJ01000027.1.
DR   AlphaFoldDB; Q8Z7H2; -.
DR   SMR; Q8Z7H2; -.
DR   STRING; 220341.16502400; -.
DR   EnsemblBacteria; AAO69314; AAO69314; t1689.
DR   KEGG; stt:t1689; -.
DR   KEGG; sty:STY1271; -.
DR   PATRIC; fig|220341.7.peg.1276; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_1_6; -.
DR   OMA; QLWGYPP; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Growth regulation; Phosphoprotein;
KW   Repressor; Transcription; Transcription regulation;
KW   Two-component regulatory system; Virulence.
FT   CHAIN           1..224
FT                   /note="Virulence transcriptional regulatory protein PhoP"
FT                   /id="PRO_0000081200"
FT   DOMAIN          3..117
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        125..223
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         52
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   224 AA;  25623 MW;  17BF6002132BF4B1 CRC64;
     MMRVLVVEDN ALLRHHLKVQ LQDSGHQVDA AEDAREADYY LNEHLPDIAI VDLGLPDEDG
     LSLIRRWRSS DVSLPVLVLT AREGWQDKVE VLSSGADDYV TKPFHIEEVM ARMQALMRRN
     SGLASQVINI SPFQVDLSRR ELSVNEEVIK LTAFEYTIME TLIRNNGKVV SKDSLMLQLY
     PDAELRESHT IDVLMGRLRK KIQAQYPHDV ITTVRGQGYL FELR