位置:首页 > 蛋白库 > PHOP_SHIFL
PHOP_SHIFL
ID   PHOP_SHIFL              Reviewed;         223 AA.
AC   Q83RR0; Q7C202;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Virulence transcriptional regulatory protein PhoP;
GN   Name=phoP; OrderedLocusNames=SF1149, S1232;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
RN   [3]
RP   FUNCTION.
RC   STRAIN=M90T / Serotype 5a;
RX   PubMed=11207599; DOI=10.1046/j.1462-5822.2000.00065.x;
RA   Moss J.E., Fisher P.E., Vick B., Groisman E.A., Zychlinsky A.;
RT   "The regulatory protein PhoP controls susceptibility to the host
RT   inflammatory response in Shigella flexneri.";
RL   Cell. Microbiol. 2:443-452(2000).
CC   -!- FUNCTION: Member of the two-component regulatory system PhoQ/PhoP
CC       involved in virulence and adaptation to low Mg(2+) environments.
CC       Necessary for resistance to killing by polymorphonuclear leukocytes
CC       (PMNs) and cationic antimicrobial peptides (CAMP) they produce.
CC       {ECO:0000269|PubMed:11207599}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by PhoQ. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005674; AAN42766.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP16655.1; -; Genomic_DNA.
DR   RefSeq; NP_707059.1; NC_004337.2.
DR   RefSeq; WP_001265481.1; NZ_WPGW01000001.1.
DR   AlphaFoldDB; Q83RR0; -.
DR   SMR; Q83RR0; -.
DR   STRING; 198214.SF1149; -.
DR   PRIDE; Q83RR0; -.
DR   EnsemblBacteria; AAN42766; AAN42766; SF1149.
DR   EnsemblBacteria; AAP16655; AAP16655; S1232.
DR   GeneID; 1024087; -.
DR   GeneID; 67414323; -.
DR   KEGG; sfl:SF1149; -.
DR   KEGG; sfx:S1232; -.
DR   PATRIC; fig|198214.7.peg.1350; -.
DR   HOGENOM; CLU_000445_30_1_6; -.
DR   OMA; QLWGYPP; -.
DR   OrthoDB; 1020672at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW   Repressor; Transcription; Transcription regulation;
KW   Two-component regulatory system; Virulence.
FT   CHAIN           1..223
FT                   /note="Virulence transcriptional regulatory protein PhoP"
FT                   /id="PRO_0000081202"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        124..222
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   223 AA;  25535 MW;  8BFF22E04F8846EC CRC64;
     MRVLVVEDNA LLRHHLKVQI QDAGHQVDDA EDAKEADYYL NEHLPDIAIV DLGLPDEDGL
     SLIRRWRSND VSLPILVLTA RESWQDKVEV LSAGADDYVT KPFHIEEVMA RMQALMRRNS
     GLASQVISLP PFQVDLSRRE LSINDEVIKL TAFEYTIMET LIRNNGKVVS KDSLMLQLYP
     DAELRESHTI DVLMGRLRKK IQAQYPQEVI TTVRGQGYLF ELR
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024