PHOSP_HENDH
ID PHOSP_HENDH Reviewed; 707 AA.
AC O55778; O89340; Q66759;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 02-JUN-2021, entry version 78.
DE RecName: Full=Phosphoprotein;
DE Short=Protein P;
GN Name=P/V/C;
OS Hendra virus (isolate Horse/Autralia/Hendra/1994).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC Henipavirus.
OX NCBI_TaxID=928303;
OH NCBI_TaxID=9796; Equus caballus (Horse).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9402; Pteropus alecto (Black flying fox).
OH NCBI_TaxID=9403; Pteropus poliocephalus (Grey-headed flying fox).
OH NCBI_TaxID=94117; Pteropus scapulatus (Little red flying fox).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 402-707.
RX PubMed=8822631; DOI=10.1016/0168-1702(96)01308-1;
RA Gould A.R.;
RT "Comparison of the deduced matrix and fusion protein sequences of equine
RT morbillivirus with cognate genes of the Paramyxoviridae.";
RL Virus Res. 43:17-31(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9445051; DOI=10.1128/jvi.72.2.1482-1490.1998;
RA Wang L.-F., Michalski W.P., Yu M., Pritchard L.I., Crameri G., Shiell B.,
RA Eaton B.T.;
RT "A novel P/V/C gene in a new member of the Paramyxoviridae family, which
RT causes lethal infection in humans, horses, and other animals.";
RL J. Virol. 72:1482-1490(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=11024125; DOI=10.1128/jvi.74.21.9972-9979.2000;
RA Wang L.-F., Yu M., Hansson E., Pritchard L.I., Shiell B., Michalski W.P.,
RA Eaton B.T.;
RT "The exceptionally large genome of Hendra virus: support for creation of a
RT new genus within the family Paramyxoviridae.";
RL J. Virol. 74:9972-9979(2000).
CC -!- FUNCTION: Essential component of the RNA polymerase transcription and
CC replication complex. Binds the viral ribonucleocapsid and positions the
CC L polymerase on the template (By similarity). {ECO:0000250}.
CC -!- RNA EDITING: Modified_positions=407; Note=Partially edited. RNA editing
CC at this position consists of an insertion of one or two guanine
CC nucleotides. The sequence displayed here is the P protein, derived from
CC the unedited RNA. The edited RNA gives rise to the V protein (+1G) (AC
CC O55777), and the W protein (+2G) (AC P0C1C6).;
CC -!- MISCELLANEOUS: The P/V/C gene has two overlapping open reading frames.
CC One encodes the P/V/W proteins and the other the C protein.
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DR EMBL; U49404; AAB39503.1; -; Genomic_RNA.
DR EMBL; AF010304; AAC04240.1; -; mRNA.
DR EMBL; AF017149; AAC83188.2; -; Genomic_RNA.
DR PIR; T08207; T08207.
DR RefSeq; NP_047107.2; NC_001906.3.
DR PDB; 4HEO; X-ray; 1.65 A; A/B=654-707.
DR PDB; 6ILG; X-ray; 2.60 A; C=481-487.
DR PDB; 6J2D; X-ray; 2.31 A; C=481-488.
DR PDB; 6J2H; X-ray; 2.30 A; C/F=481-488.
DR PDB; 6K7T; X-ray; 1.60 A; C=481-488.
DR PDBsum; 4HEO; -.
DR PDBsum; 6ILG; -.
DR PDBsum; 6J2D; -.
DR PDBsum; 6J2H; -.
DR PDBsum; 6K7T; -.
DR SMR; O55778; -.
DR GeneID; 1446469; -.
DR KEGG; vg:1446469; -.
DR Proteomes; UP000008771; Genome.
DR GO; GO:0032991; C:protein-containing complex; IDA:CAFA.
DR GO; GO:0097718; F:disordered domain specific binding; IPI:CAFA.
DR DisProt; DP00700; -.
DR InterPro; IPR004897; P/V_Pprotein_paramyxoviral.
DR InterPro; IPR028243; Paramyxo_P/V_N.
DR InterPro; IPR035430; Paramyxo_PNT.
DR InterPro; IPR025909; Soyouz_module.
DR Pfam; PF03210; Paramyx_P_V_C; 1.
DR Pfam; PF13825; Paramyxo_P_V_N; 1.
DR Pfam; PF14320; Paramyxo_PNT; 1.
DR Pfam; PF14313; Soyouz_module; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Coiled coil; Phosphoprotein; Reference proteome; RNA editing;
KW Viral RNA replication.
FT CHAIN 1..707
FT /note="Phosphoprotein"
FT /id="PRO_0000236012"
FT REGION 26..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 193..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..590
FT /note="L protein binding"
FT /evidence="ECO:0000250"
FT COILED 496..574
FT /evidence="ECO:0000250"
FT COMPBIAS 73..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..314
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 257
FT /note="Phosphoserine; by host"
FT /evidence="ECO:0000250"
FT MOD_RES 350
FT /note="Phosphoserine; by host"
FT /evidence="ECO:0000250"
FT CONFLICT 408
FT /note="A -> V (in Ref. 1; AAB39503)"
FT /evidence="ECO:0000305"
FT CONFLICT 474..485
FT /note="KYIMPSDDFANT -> NILCHQMILLTL (in Ref. 1; AAB39503)"
FT /evidence="ECO:0000305"
FT CONFLICT 574
FT /note="I -> M (in Ref. 1; AAB39503)"
FT /evidence="ECO:0000305"
FT CONFLICT 688..707
FT /note="TDEEVQEVANTVNDIIDGNI -> QMKRFRRWPIQSMILLMGTSKHVSNLIE
FT (in Ref. 1; AAB39503)"
FT /evidence="ECO:0000305"
FT HELIX 656..669
FT /evidence="ECO:0007829|PDB:4HEO"
FT HELIX 673..685
FT /evidence="ECO:0007829|PDB:4HEO"
FT HELIX 689..703
FT /evidence="ECO:0007829|PDB:4HEO"
SQ SEQUENCE 707 AA; 78306 MW; 7E8B7E69892C0787 CRC64;
MDKLDLVNDG LDIIDFIQKN QKEIQKTYGR SSIQQPSTKD RTRAWEDFLQ STSGEHEQAE
GGMPKNDGGT EGRNVEDLSS VTSSDGTIGQ RVSNTRAWAE DPDDIQLDPM VTDVVYHDHG
GECTGHGPSS SPERGWSYHM SGTHDGNVRA VPDTKVLPNA PKTTVPEEVR EIDLIGLEDK
FASAGLNPAA VPFVPKNQST PTEEPPVIPE YYYGSGRRGD LSKSPPRGNV NLDSIKIYTS
DDEDENQLEY EDEFAKSSSE VVIDTTPEDN DSINQEEVVG DPSDQGLEHP FPLGKFPEKE
ETPDVRRKDS LMQDSCKRGG VPKRLPMLSE EFECSGSDDP IIQELEREGS HPGGSLRLRE
PPQSSGNSRN QPDRQLKTGD AASPGGVQRP GTPMPKSRIM PIKKGTDAKS QYVGTEDVPG
SKSGATRYVR GLPPNQESKS VTAENVQLSA PSAVTRNEGH DQEVTSNEDS LDDKYIMPSD
DFANTFLPHD TDRLNYHADH LNDYDLETLC EESVLMGIVN AIKLINIDMR LNHIEEQMKE
IPKIINKIDS IDRVLAKTNT ALSTIEGHLV SMMIMIPGKG KGERKGKTNP ELKPVIGRNI
LEQQELFSFD NLKNFRDGSL TDEPYGGVAR IRDDLILPEL NFSETNASQF VPLADDASKD
VVRTMIRTHI KDRELRSELM DYLNRAETDE EVQEVANTVN DIIDGNI
