ID   PHOSP_MEASA             Reviewed;         507 AA.
AC   P35974;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   29-SEP-2021, entry version 82.
DE   RecName: Full=Phosphoprotein;
DE            Short=Protein P;
GN   Name=P/V;
OS   Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose
OS   panencephalitis virus).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC   Morbillivirus.
OX   NCBI_TaxID=36408;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8470368; DOI=10.1007/bf01702349;
RA   Mori T., Sasaki K., Hashimoto H., Makino S.;
RT   "Molecular cloning and complete nucleotide sequence of genomic RNA of the
RT   AIK-C strain of attenuated measles virus.";
RL   Virus Genes 7:67-81(1993).
RN   [2]
RP   RNA EDITING.
RX   PubMed=11134304; DOI=10.1128/jvi.75.2.910-920.2001;
RA   Parks C.L., Lerch R.A., Walpita P., Wang H.P., Sidhu M.S., Udem S.A.;
RT   "Comparison of predicted amino acid sequences of measles virus strains in
RT   the Edmonston vaccine lineage.";
RL   J. Virol. 75:910-920(2001).
CC   -!- FUNCTION: Essential component of the RNA polymerase and the nascent
CC       chain assembly complex. Also required during RNA synthesis.
CC   -!- RNA EDITING: Modified_positions=231 {ECO:0000269|PubMed:11134304};
CC       Note=Partially edited. RNA editing at this position consists of an
CC       insertion of one guanine nucleotide. The sequence displayed here is the
CC       P protein, derived from the unedited RNA. The edited RNA gives rise to
CC       the V protein (AC Q9IC37).;
CC   -!- SIMILARITY: Belongs to the morbillivirus P protein family.
CC       {ECO:0000305}.
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DR   EMBL; S58435; AAB26142.1; -; Genomic_RNA.
DR   PIR; B48556; B48556.
DR   PDB; 4BHV; X-ray; 2.10 A; A/B/C/D=304-360.
DR   PDB; 4C5Q; X-ray; 2.20 A; A/B/C/D/E/F/G/H=304-375.
DR   PDBsum; 4BHV; -.
DR   PDBsum; 4C5Q; -.
DR   BMRB; P35974; -.
DR   SMR; P35974; -.
DR   Proteomes; UP000007775; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR   InterPro; IPR004897; P/V_Pprotein_paramyxoviral.
DR   InterPro; IPR028243; Paramyxo_P/V_N.
DR   InterPro; IPR016075; RNA_pol_Pprot-P_XD_paramyxovir.
DR   Pfam; PF03210; Paramyx_P_V_C; 1.
DR   Pfam; PF13825; Paramyxo_P_V_N; 1.
DR   SUPFAM; SSF101089; SSF101089; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Phosphoprotein; RNA editing; Viral RNA replication.
FT   CHAIN           1..507
FT                   /note="Phosphoprotein"
FT                   /id="PRO_0000142689"
FT   REGION          41..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          201..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           309..340
FT                   /evidence="ECO:0007829|PDB:4BHV"
FT   HELIX           342..360
FT                   /evidence="ECO:0007829|PDB:4BHV"
SQ   SEQUENCE   507 AA;  54101 MW;  BCD6D2CA9075CE07 CRC64;
     MAEEQARHVK NGLECIRALK AEPIGSLAIE EAMAAWSEIS DNPGQERATC REEKAGSSGL
     SKPCLSAIGS TEGGAPRIRG QGPGESDDDA ETLGIPPRNL QASSTGLQCY YVYDHSGEAV
     KGIQDADSIM VQSGLDGDST LSGGDNESEN SDVDIGEPDT EGYAITDRGS APISMGFRAS
     DVETAEGGEI HELLRLQSRG NNFPKLGKTL NVPPPPDPGR ASTSGTPIKK GTERRLASFG
     TEIASLLTGG ATQCARKSPS EPSGPGAPAG NVPEYVSNAA LIQEWTPESG TTISPRSQNN
     EEGGDYYDDE LFSDVQDIKT ALAKIHEDNQ KIISKLESLL LLKGEVESIK KQINRQNISI
     STLEGHLSSI MIAIPGLGKD PNDPTADVEI NPDLKPIIGR DSGRALAEVL KKPVASRQLQ
     GMTNGRTSSR GQLLKEFQPK PIGKKMSSAV GFVPDTGPAS RSVIRSIIKS SRLEEDRKRY
     LMTLLDDIKG ANDLAKFHQM LMKIIMK