ID   PHOSP_MEASE             Reviewed;         507 AA.
AC   P03422;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   02-JUN-2021, entry version 102.
DE   RecName: Full=Phosphoprotein;
DE            Short=Protein P;
GN   Name=P/V;
OS   Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis
OS   virus).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC   Morbillivirus.
OX   NCBI_TaxID=11235;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3882996; DOI=10.1128/jvi.53.3.908-919.1985;
RA   Bellini W.J., Englund G., Rozenblatt S., Arnheiter H., Richardson C.D.;
RT   "Measles virus P gene codes for two proteins.";
RL   J. Virol. 53:908-919(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 401-507.
RX   PubMed=6547185; DOI=10.1128/jvi.50.3.939-942.1984;
RA   Bellini W.J., Englund G., Richardson C.D., Rozenblatt S.;
RT   "Positive identification of a measles virus cDNA clone encoding a region of
RT   the phosphoprotein.";
RL   J. Virol. 50:939-942(1984).
CC   -!- FUNCTION: Essential component of the RNA polymerase and the nascent
CC       chain assembly complex. Also required during RNA synthesis.
CC   -!- INTERACTION:
CC       P03422; Q89933: N; Xeno; NbExp=3; IntAct=EBI-8589851, EBI-8589867;
CC   -!- RNA EDITING: Modified_positions=231 {ECO:0000250}; Note=Partially
CC       edited. RNA editing at this position consists of an insertion of one
CC       guanine nucleotide. The sequence displayed here is the P protein,
CC       derived from the unedited RNA. The edited RNA gives rise to the V
CC       protein (AC Q9EMA9) (By similarity). {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the morbillivirus P protein family.
CC       {ECO:0000305}.
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DR   EMBL; M10456; AAA46437.1; -; Genomic_RNA.
DR   EMBL; K02912; AAA46436.1; -; Genomic_RNA.
DR   PIR; A04038; RRNZM.
DR   PDB; 1OKS; X-ray; 1.80 A; A=459-507.
DR   PDB; 2K9D; NMR; -; A=462-505.
DR   PDBsum; 1OKS; -.
DR   PDBsum; 2K9D; -.
DR   BMRB; P03422; -.
DR   SMR; P03422; -.
DR   IntAct; P03422; 1.
DR   MINT; P03422; -.
DR   DrugBank; DB03309; N-cyclohexyltaurine.
DR   EvolutionaryTrace; P03422; -.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR   DisProt; DP00133; -.
DR   InterPro; IPR004897; P/V_Pprotein_paramyxoviral.
DR   InterPro; IPR028243; Paramyxo_P/V_N.
DR   InterPro; IPR016075; RNA_pol_Pprot-P_XD_paramyxovir.
DR   Pfam; PF03210; Paramyx_P_V_C; 1.
DR   Pfam; PF13825; Paramyxo_P_V_N; 1.
DR   SUPFAM; SSF101089; SSF101089; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Phosphoprotein; RNA editing; Viral RNA replication.
FT   CHAIN           1..507
FT                   /note="Phosphoprotein"
FT                   /id="PRO_0000142690"
FT   REGION          41..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          201..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        435..436
FT                   /note="KE -> RQ (in Ref. 2; AAA46436)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        464
FT                   /note="I -> T (in Ref. 2; AAA46436)"
FT                   /evidence="ECO:0000305"
FT   HELIX           461..470
FT                   /evidence="ECO:0007829|PDB:1OKS"
FT   HELIX           475..487
FT                   /evidence="ECO:0007829|PDB:1OKS"
FT   HELIX           491..507
FT                   /evidence="ECO:0007829|PDB:1OKS"
SQ   SEQUENCE   507 AA;  54057 MW;  17F6B60CC0A78637 CRC64;
     MAEEQARHVK NGLECIRALK AEPIGSLAIE EAMAAWSEIS DNPGQERATC REEKAGSSGL
     SKPCLSAIGS TEGGAPRIRG QGPGESDDDA ETLGIPPRNL QASSTGLQCY YVYDHSGEAV
     KGIQDADSIM VQSGLDGDST LSGGDNESEN SDVDIGEPDT EGYAITDRGS APISMGFRAS
     DVETAEGGEI HELLRLQSRG NNFPKLGKTL NVPPPPDPGR ASTSGTPIKK GTERRLASFG
     TEIASLLTGG ATQCARKSPS EPSGPGAPAG NVPECVSNAA LIQEWTPESG TTISPRSQNN
     EEGGDYYDDE LFSDVQDIKT ALAKIHEDNQ KIISKLESLL LLKGEVESIK KQINRQNISI
     STLEGHLSSI MIAIPGLGKD PNDPTADVEI NPDLKPIIGR DSGRALAEVL KKPVASRQLQ
     GMTNGRTSSR GQLLKEFQLK PIGKKMSSAV GFVPDTGPAS RSVIRSIIKS SRLEEDRKRY
     LMTLLDDIKG ANDLAKFHQM LMKIIMK