PHOSP_PI3H4
ID PHOSP_PI3H4 Reviewed; 604 AA.
AC P06162;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1988, sequence version 1.
DT 02-JUN-2021, entry version 84.
DE RecName: Full=Phosphoprotein;
DE Short=Protein P;
GN Name=P/V/D;
OS Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human
OS parainfluenza 3 virus (strain NIH 47885)).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC Respirovirus.
OX NCBI_TaxID=11217;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=3016995; DOI=10.1016/0042-6822(86)90036-x;
RA Luk D., Sanchez A., Banerjee A.K.;
RT "Messenger RNA encoding the phosphoprotein (P) gene of human parainfluenza
RT virus 3 is bicistronic.";
RL Virology 153:318-325(1986).
RN [2]
RP ERRATUM OF PUBMED:3016995, AND SEQUENCE REVISION.
RA Luk D., Sanchez A., Banerjee A.K.;
RL Virology 156:193-194(1987).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=3022477; DOI=10.1016/0042-6822(86)90167-4;
RA Galinski M.S., Mink M.A., Lambert D.M., Wechsler S.L., Pons W.M.;
RT "Molecular cloning and sequence analysis of the human parainfluenza 3 virus
RT mRNA encoding the P and C proteins.";
RL Virology 155:46-60(1986).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3025346; DOI=10.1099/0022-1317-67-12-2705;
RA Spriggs M.K., Collins P.L.;
RT "Sequence analysis of the P and C protein genes of human parainfluenza
RT virus type 3: patterns of amino acid sequence homology among paramyxovirus
RT proteins.";
RL J. Gen. Virol. 67:2705-2719(1986).
CC -!- FUNCTION: Essential component of the RNA polymerase and the nascent
CC chain assembly complex. Also required during RNA synthesis.
CC -!- RNA EDITING: Modified_positions=Undetermined; Note=Partially edited.
CC RNA editing consists of an insertion of one to six guanine nucleotides.
CC The sequence displayed here is the P protein, derived from the unedited
CC RNA. The edited RNA versions give rise to the V protein and the D
CC protein depending on the number of inserted nucleotides.
CC {ECO:0000250|UniProtKB:P06163};
CC -!- SIMILARITY: Belongs to the respirovirus P protein family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M14890; AAA46866.1; ALT_SEQ; Genomic_RNA.
DR EMBL; X04721; CAA28429.1; -; Genomic_RNA.
DR EMBL; M14932; AAA66818.1; -; Genomic_RNA.
DR EMBL; D10029; BAA00921.1; ALT_SEQ; mRNA.
DR PIR; A94355; RRNZP4.
DR SMR; P06162; -.
DR DIP; DIP-616N; -.
DR PRIDE; P06162; -.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR InterPro; IPR002693; Paramyxo_PProtein_C.
DR InterPro; IPR016075; RNA_pol_Pprot-P_XD_paramyxovir.
DR Pfam; PF01806; Paramyxo_P; 1.
DR SUPFAM; SSF101089; SSF101089; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; RNA editing; Viral RNA replication.
FT CHAIN 1..604
FT /note="Phosphoprotein"
FT /id="PRO_0000142706"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 39..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 198
FT /note="P -> N (in Ref. 4; CAA28429)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="Missing (in Ref. 3; AAA66818 and 4; BAA00921)"
FT /evidence="ECO:0000305"
FT CONFLICT 316
FT /note="Q -> R (in Ref. 3; AAA66818)"
FT /evidence="ECO:0000305"
FT CONFLICT 584
FT /note="C -> S (in Ref. 4; CAA28429)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 604 AA; 67662 MW; D2E06EF47027D0BD CRC64;
MESDAKNYQI MDSWEEEPRD KSTNISSALN IIEFILSTDP QEDLSENDTI NTRTQQLSAT
ICQPEIKPTE TSEKVSGSTD KNRQSGSSHE CTTEAKDRNI DQETVQGGSG RRSSSDSRAE
TVVSGGISGS ITDSKNGTQN TENIDLNEIR KMDKDSIERK MRQSADVPSE ISGSDVIFTT
EQSRNSDHGR SLEPISTPDT RSMSVVTAAT PDDEEEILMK NSRMKKSSST HQEDDKRIKK
GGGGKGKDWF KKSRDTDNQT STSDHKPTSK GQKKISKTTT TNTDTKGQTE TQTESSETQS
PSWNPIIDNN TDRTEQTSTT PPTTTPRSTR TKESIRTNSE SKPKTQKTIG KERKDTEESN
RFTERAITLL QNLGVIQSTS KLDLYQDKRV VCVANVLNNV DTASKIDFLA GLVIGVSMDN
DTKLIQIQNE MLNLKADLKR MDESHRRLIE NQREQLSLIT SLISNLKIMT ERGGKKDQNE
SNERVSMIKT KLKEEKIKKT RFDPLMEAQG IDKNIPDLYR HAGNTLENDV QVKSEILSSY
NESNATRLIP RKVSSTMRSL VAVINNSNLP QSTKQSYINE LKHCKSDEEV SELMDMFNED
VNNC
