ID   PHOSP_TUPVT             Reviewed;         337 AA.
AC   Q4VKV7;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   23-FEB-2022, entry version 30.
DE   RecName: Full=Phosphoprotein;
DE            Short=P protein;
GN   Name=P;
OS   Tupaia virus (isolate Tupaia/Thailand/-/1986) (TUPV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC   Tupavirus.
OX   NCBI_TaxID=1560034;
OH   NCBI_TaxID=9394; Tupaia.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15890917; DOI=10.1128/jvi.79.11.6781-6790.2005;
RA   Springfeld C., Darai G., Cattaneo R.;
RT   "Characterization of the Tupaia rhabdovirus genome reveals a long open
RT   reading frame overlapping with P and a novel gene encoding a small
RT   hydrophobic protein.";
RL   J. Virol. 79:6781-6790(2005).
CC   -!- FUNCTION: Essential component of the RNA polymerase transcription and
CC       replication complex. Binds the viral ribonucleocapsid and positions the
CC       L polymerase on the template. May act as a chaperone for newly
CC       synthesized free N protein, so-called N(0). Plays a role in virion
CC       assembly. {ECO:0000250|UniProtKB:P03520}.
CC   -!- SUBUNIT: Homotrimer. This trimer is stabilized by binding to the L
CC       protein. Binds N(0), and N in ribonucleocapsid.
CC       {ECO:0000250|UniProtKB:P03520}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P03520}. Host
CC       cytoplasm {ECO:0000250|UniProtKB:P03520}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=Phosphoprotein;
CC         IsoId=Q4VKV7-1; Sequence=Displayed;
CC       Name=Protein C;
CC         IsoId=Q4VKV6-1; Sequence=External;
CC   -!- PTM: Phosphorylated by host kinases. Phosphorylation play an important
CC       role in facilitating trimerization and possibly P-L complex formation.
CC       {ECO:0000250|UniProtKB:P03520}.
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DR   EMBL; AY840978; AAX47597.1; -; Genomic_RNA.
DR   RefSeq; YP_238529.1; NC_007020.1.
DR   GeneID; 3416611; -.
DR   KEGG; vg:3416611; -.
DR   Proteomes; UP000029771; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019083; P:viral transcription; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Alternative initiation; Chaperone; Host cytoplasm; Phosphoprotein;
KW   Reference proteome; Viral RNA replication; Viral transcription; Virion.
FT   CHAIN           1..337
FT                   /note="Phosphoprotein"
FT                   /id="PRO_0000432069"
FT   REGION          77..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..185
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   337 AA;  37286 MW;  A745DD13E4943992 CRC64;
     MTDPKKISRV ALKGYDLTKV SRALEECEDQ PGVRVGGVQI VSGGEAEAPA HLEDNRQGAI
     GDNFDVFSRD SKNVQIVTEH EDSSDEEYEE ARSYGDDSGH QPNRAAVPFA DDEYGDFKRA
     RERLPQLFHE GWGFGSQQAN EESSEGLQQQ SGECGSGGGS SNAGGKDEDD LQEKTGHEKE
     KSVIVPPKES GSVSGYHGSC DIPFNMEEFL ASPATTQRRQ LLELCQLIAD RSNEELIFFP
     WGFNLVKRKV HRVEPQQPVA VSHRFTWEDF QLKLKAGFTL IHKKTKAPVV LNSSSYNLGS
     VPEGGISLSP DDTELSVLIK CLRYLGLYKF LATQIEF