ID   PHOS_FELCA              Reviewed;         245 AA.
AC   P41686;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Phosducin;
DE            Short=PHD;
DE   AltName: Full=33 kDa phototransducing protein;
GN   Name=PDC;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Abyssinian; TISSUE=Retina;
RX   PubMed=7873608; DOI=10.1016/0167-4781(94)00231-q;
RA   Gorin M.B., To A.C., Narfstrom K.;
RT   "Sequence analysis and exclusion of phosducin as the gene for the recessive
RT   retinal degeneration of the Abyssinian cat.";
RL   Biochim. Biophys. Acta 1260:323-327(1995).
CC   -!- FUNCTION: Inhibits the transcriptional activation activity of the cone-
CC       rod homeobox CRX (By similarity). May participate in the regulation of
CC       visual phototransduction or in the integration of photoreceptor
CC       metabolism. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CRX (By similarity). Forms a complex with the
CC       beta and gamma subunits of the GTP-binding protein, transducin.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P20941}. Nucleus {ECO:0000250|UniProtKB:P20941}.
CC       Cell projection, cilium, photoreceptor outer segment
CC       {ECO:0000250|UniProtKB:P19632}. Photoreceptor inner segment
CC       {ECO:0000250|UniProtKB:P19632}.
CC   -!- PTM: Light-induced changes in cyclic nucleotide levels modulate the
CC       phosphorylation of this protein by cAMP kinase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the phosducin family. {ECO:0000305}.
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DR   EMBL; L35314; AAB59257.1; -; mRNA.
DR   PIR; S52096; S52096.
DR   RefSeq; NP_001036805.1; NM_001043340.1.
DR   RefSeq; XP_019676889.1; XM_019821330.1.
DR   RefSeq; XP_019676890.1; XM_019821331.1.
DR   AlphaFoldDB; P41686; -.
DR   SMR; P41686; -.
DR   STRING; 9685.ENSFCAP00000024306; -.
DR   Ensembl; ENSFCAT00000055851; ENSFCAP00000042287; ENSFCAG00000045009.
DR   GeneID; 751516; -.
DR   KEGG; fca:751516; -.
DR   CTD; 5132; -.
DR   eggNOG; KOG3171; Eukaryota.
DR   GeneTree; ENSGT00940000156236; -.
DR   HOGENOM; CLU_085598_1_0_1; -.
DR   InParanoid; P41686; -.
DR   OMA; CRKMSMQ; -.
DR   OrthoDB; 1324495at2759; -.
DR   Proteomes; UP000011712; Chromosome F1.
DR   Bgee; ENSFCAG00000045009; Expressed in eyeball of camera-type eye and 4 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001917; C:photoreceptor inner segment; IEA:UniProtKB-SubCell.
DR   GO; GO:0001750; C:photoreceptor outer segment; IBA:GO_Central.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd02987; Phd_like_Phd; 1.
DR   Gene3D; 1.10.168.10; -; 2.
DR   InterPro; IPR001200; Phosducin.
DR   InterPro; IPR023196; Phosducin_N_dom_sf.
DR   InterPro; IPR024253; Phosducin_thioredoxin-like_dom.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF02114; Phosducin; 1.
DR   PRINTS; PR00677; PHOSDUCIN.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Nucleus; Phosphoprotein;
KW   Reference proteome; Sensory transduction; Vision.
FT   CHAIN           1..245
FT                   /note="Phosducin"
FT                   /id="PRO_0000163750"
FT   REGION          1..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          111..245
FT                   /note="Thioredoxin fold"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        26..45
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         73
FT                   /note="Phosphoserine; by PKA"
FT                   /evidence="ECO:0000250|UniProtKB:P19632"
SQ   SEQUENCE   245 AA;  28364 MW;  9807CD30C32F8B21 CRC64;
     MEEAKSQSLE EDFEGQATHT GPKGVINDWR KFKLESEDSD SVPPSKKEIL RQMSSPQSRD
     NKDSKERFSR KMSIQEYELI HRDKEDENCL RKYRRQCMQD MHQKLSFGPR YGFVYELETG
     EQFLETIEKE QKITTIVVHI YEDGIKGCDA LNSSFTCLAV EYPMVKFCKI KASNTGARDR
     FSSDVLPTLL VYKGGELISN FISVSEQFAE EFFAGDVESF LNEYGLLPER ETHALDQTNM
     EEDIE