ID   PHOS_HORSE              Reviewed;         245 AA.
AC   Q9XS39;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Phosducin;
DE            Short=PHD;
GN   Name=PDC;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Icelandic; TISSUE=Pineal gland, and Retina;
RX   PubMed=11197562; DOI=10.2460/ajvr.2001.62.61;
RA   Keller C., Schulz R.;
RT   "Nucleotide and deduced amino acid sequence of equine retinal and pineal
RT   gland phosducin.";
RL   Am. J. Vet. Res. 62:61-66(2001).
CC   -!- FUNCTION: May participate in the regulation of visual phototransduction
CC       or in the integration of photoreceptor metabolism. Inhibits the
CC       transcriptional activation activity of the cone-rod homeobox CRX (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with the beta and gamma subunits of the GTP-
CC       binding protein, transducin. Interacts with CRX (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P20941}. Nucleus {ECO:0000250|UniProtKB:P20941}.
CC       Cell projection, cilium, photoreceptor outer segment
CC       {ECO:0000250|UniProtKB:P19632}. Photoreceptor inner segment
CC       {ECO:0000250|UniProtKB:P19632}.
CC   -!- PTM: Light-induced changes in cyclic nucleotide levels modulate the
CC       phosphorylation of this protein by cAMP kinase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the phosducin family. {ECO:0000305}.
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DR   EMBL; AF135443; AAD26865.1; -; mRNA.
DR   EMBL; AF155881; AAD38848.1; -; mRNA.
DR   EMBL; AF162703; AAD47064.1; -; mRNA.
DR   RefSeq; NP_001075317.1; NM_001081848.1.
DR   RefSeq; XP_005609800.1; XM_005609743.1.
DR   AlphaFoldDB; Q9XS39; -.
DR   SMR; Q9XS39; -.
DR   STRING; 9796.ENSECAP00000013414; -.
DR   PaxDb; Q9XS39; -.
DR   Ensembl; ENSECAT00000016604; ENSECAP00000013414; ENSECAG00000015729.
DR   GeneID; 100033898; -.
DR   KEGG; ecb:100033898; -.
DR   CTD; 5132; -.
DR   VGNC; VGNC:50858; PDC.
DR   GeneTree; ENSGT00940000156236; -.
DR   HOGENOM; CLU_085598_1_0_1; -.
DR   InParanoid; Q9XS39; -.
DR   OrthoDB; 1324495at2759; -.
DR   Proteomes; UP000002281; Chromosome 5.
DR   Bgee; ENSECAG00000015729; Expressed in retina and 2 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001917; C:photoreceptor inner segment; IEA:UniProtKB-SubCell.
DR   GO; GO:0001750; C:photoreceptor outer segment; IBA:GO_Central.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd02987; Phd_like_Phd; 1.
DR   Gene3D; 1.10.168.10; -; 2.
DR   InterPro; IPR001200; Phosducin.
DR   InterPro; IPR023196; Phosducin_N_dom_sf.
DR   InterPro; IPR024253; Phosducin_thioredoxin-like_dom.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   Pfam; PF02114; Phosducin; 1.
DR   PRINTS; PR00677; PHOSDUCIN.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Nucleus; Phosphoprotein;
KW   Reference proteome; Sensory transduction; Vision.
FT   CHAIN           1..245
FT                   /note="Phosducin"
FT                   /id="PRO_0000163751"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          111..245
FT                   /note="Thioredoxin fold"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..45
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..67
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         73
FT                   /note="Phosphoserine; by PKA"
FT                   /evidence="ECO:0000250|UniProtKB:P19632"
SQ   SEQUENCE   245 AA;  28214 MW;  60C58E0DEBA63C3A CRC64;
     MEEARRQSLE EDFEGQATHT GPKGVINDWR KFKLESEDSD SIPPCKKEIL KQMSSPQSRD
     DKDSKERFSR KMSIQEYELI HQDKEDENCL RKYRRQCMQD MHQKLSFGPR YGFVYELETG
     EQFLETIEKE QKITTIVVHI YEDGIKGCDA LNSSLACLAA EYPMVKFCKI KASNTGAGDR
     FSSDVLPTLL VYKGGELISN FLSVAEQFAE EFFAGDVESF LNEYGLLPER EIHALEQTSM
     EEDVE