PHOS_MOUSE
ID PHOS_MOUSE Reviewed; 244 AA.
AC Q9QW08;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Phosducin;
DE Short=PHD;
DE AltName: Full=33 kDa phototransducing protein;
DE AltName: Full=Rod photoreceptor 1;
DE Short=RPR-1;
GN Name=Pdc; Synonyms=Rpr1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Retina;
RX PubMed=8405193; DOI=10.1006/exer.1993.1122;
RA Groshan K.R., Norton J.C., Craft C.M., Travis G.H.;
RT "Isolation and characterization of a cDNA for mouse retinal phosducin.";
RL Exp. Eye Res. 57:253-255(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8224906; DOI=10.1016/0378-1119(93)90636-h;
RA Abe T., Kikuchi T., Chang T., Shinohara T.;
RT "The sequence of the mouse phosducin-encoding gene and its 5'-flanking
RT region.";
RL Gene 133:179-186(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibits the transcriptional activation activity of the cone-
CC rod homeobox CRX (By similarity). May participate in the regulation of
CC visual phototransduction or in the integration of photoreceptor
CC metabolism. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CRX (By similarity). Forms a complex with the
CC beta and gamma subunits of the GTP-binding protein, transducin.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:P20941}. Nucleus {ECO:0000250|UniProtKB:P20941}.
CC Cell projection, cilium, photoreceptor outer segment
CC {ECO:0000250|UniProtKB:P19632}. Photoreceptor inner segment
CC {ECO:0000250|UniProtKB:P19632}.
CC -!- PTM: Light-induced changes in cyclic nucleotide levels modulate the
CC phosphorylation of this protein by cAMP kinase. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the phosducin family. {ECO:0000305}.
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DR EMBL; L08075; AAK13559.1; -; mRNA.
DR EMBL; BC012507; AAH12507.1; -; mRNA.
DR EMBL; BC021920; AAH21920.1; -; mRNA.
DR CCDS; CCDS15354.1; -.
DR PIR; JC2018; JC2018.
DR RefSeq; NP_001153202.1; NM_001159730.1.
DR RefSeq; NP_077778.1; NM_024458.2.
DR AlphaFoldDB; Q9QW08; -.
DR SMR; Q9QW08; -.
DR BioGRID; 203000; 3.
DR STRING; 10090.ENSMUSP00000131631; -.
DR iPTMnet; Q9QW08; -.
DR PhosphoSitePlus; Q9QW08; -.
DR MaxQB; Q9QW08; -.
DR PaxDb; Q9QW08; -.
DR PRIDE; Q9QW08; -.
DR ProteomicsDB; 288202; -.
DR Antibodypedia; 34456; 108 antibodies from 20 providers.
DR DNASU; 20028; -.
DR Ensembl; ENSMUST00000165062; ENSMUSP00000131631; ENSMUSG00000006007.
DR Ensembl; ENSMUST00000191228; ENSMUSP00000141136; ENSMUSG00000006007.
DR GeneID; 20028; -.
DR KEGG; mmu:20028; -.
DR UCSC; uc007cxw.1; mouse.
DR CTD; 5132; -.
DR MGI; MGI:98090; Pdc.
DR VEuPathDB; HostDB:ENSMUSG00000006007; -.
DR eggNOG; KOG3171; Eukaryota.
DR GeneTree; ENSGT00940000156236; -.
DR InParanoid; Q9QW08; -.
DR OMA; CRKMSMQ; -.
DR OrthoDB; 1324495at2759; -.
DR PhylomeDB; Q9QW08; -.
DR TreeFam; TF315179; -.
DR BioGRID-ORCS; 20028; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Pdc; mouse.
DR PRO; PR:Q9QW08; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9QW08; protein.
DR Bgee; ENSMUSG00000006007; Expressed in retinal neural layer and 59 other tissues.
DR ExpressionAtlas; Q9QW08; baseline and differential.
DR Genevisible; Q9QW08; MM.
DR GO; GO:0005829; C:cytosol; TAS:MGI.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001917; C:photoreceptor inner segment; IEA:UniProtKB-SubCell.
DR GO; GO:0001750; C:photoreceptor outer segment; IDA:MGI.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd02987; Phd_like_Phd; 1.
DR Gene3D; 1.10.168.10; -; 2.
DR InterPro; IPR001200; Phosducin.
DR InterPro; IPR023196; Phosducin_N_dom_sf.
DR InterPro; IPR024253; Phosducin_thioredoxin-like_dom.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR Pfam; PF02114; Phosducin; 1.
DR PRINTS; PR00677; PHOSDUCIN.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cytoplasm; Nucleus; Phosphoprotein;
KW Reference proteome; Sensory transduction; Vision.
FT CHAIN 1..244
FT /note="Phosducin"
FT /id="PRO_0000163753"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..244
FT /note="Thioredoxin fold"
FT /evidence="ECO:0000250"
FT COMPBIAS 26..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 71
FT /note="Phosphoserine; by PKA"
FT /evidence="ECO:0000250|UniProtKB:P19632"
SQ SEQUENCE 244 AA; 28016 MW; F42361EA25F0F254 CRC64;
MEEAASQSLE EDFEGQATHT GPKGVINDWR KFKLESEDGD SIPPSKKEIL RQMSSPQSRD
DSKERMSRKM SIQEYELIHQ DKEDESCLRK YRRQCMQDMH QKLSFGPRYG FVYELETGEQ
FLETIEKEQK VTTIVVNIYE DGVRGCDALN SSLACLAVEY PMVKFCKIKA SNTGAGDRFS
TDVLPTLLVY KGGELISNFI SVAEQFAEEF FAVDVESFLN EYGLLPEREI HDLEQTNMED
EDIE
