ID   PHOU1_METTH             Reviewed;         219 AA.
AC   O27767;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Phosphate-specific transport system accessory protein PhoU homolog 1;
DE            Short=Pst system accessory protein PhoU 1 homolog;
GN   OrderedLocusNames=MTH_1734;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Plays a role in the regulation of phosphate uptake.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PhoU family. {ECO:0000305}.
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DR   EMBL; AE000666; AAB86204.1; -; Genomic_DNA.
DR   PIR; H69098; H69098.
DR   RefSeq; WP_010877340.1; NC_000916.1.
DR   AlphaFoldDB; O27767; -.
DR   SMR; O27767; -.
DR   STRING; 187420.MTH_1734; -.
DR   EnsemblBacteria; AAB86204; AAB86204; MTH_1734.
DR   GeneID; 24854831; -.
DR   KEGG; mth:MTH_1734; -.
DR   PATRIC; fig|187420.15.peg.1693; -.
DR   HOGENOM; CLU_078518_2_0_2; -.
DR   OMA; WKHGIET; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0030643; P:cellular phosphate ion homeostasis; IEA:InterPro.
DR   GO; GO:0045936; P:negative regulation of phosphate metabolic process; ISS:UniProtKB.
DR   GO; GO:2000186; P:negative regulation of phosphate transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.220; -; 1.
DR   InterPro; IPR028366; P_transport_PhoU.
DR   InterPro; IPR038078; PhoU-like_sf.
DR   InterPro; IPR026022; PhoU_dom.
DR   PANTHER; PTHR42930; PTHR42930; 1.
DR   Pfam; PF01895; PhoU; 2.
DR   PIRSF; PIRSF003107; PhoU; 1.
DR   TIGRFAMs; TIGR02135; phoU_full; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphate transport; Reference proteome; Transport.
FT   CHAIN           1..219
FT                   /note="Phosphate-specific transport system accessory
FT                   protein PhoU homolog 1"
FT                   /id="PRO_0000155189"
SQ   SEQUENCE   219 AA;  25642 MW;  3A73280C6648B047 CRC64;
     MEKKYPRILF RKRLKDLRKD MEEVSQKTLK THKLAVDLLM EYDEEKKEKV IKNSRAIDDM
     VFNLERKAIS LIAAEQPVAG DLRFIEACIK VGSHLKRIGY LAANIAEAAE KLKDEEIPRR
     PLEDLKHMSD FVQMMLSKGI YAFLDQNMEM ARELRHDDDK VDDLFDQTLE HVTRSMFEDK
     ESISYLVNLL FIARFLERVG DRAVSIADRT IFMITCEKP