ID   PHOU1_MYCLE             Reviewed;         222 AA.
AC   Q50047;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Phosphate-specific transport system accessory protein PhoU homolog 1;
DE            Short=Pst system accessory protein PhoU homolog 1;
GN   Name=phoU1; Synonyms=phoY, phoY1; OrderedLocusNames=ML2188;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Plays a role in the regulation of phosphate uptake.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PhoU family. {ECO:0000305}.
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DR   EMBL; U15182; AAA62992.1; -; Genomic_DNA.
DR   EMBL; AL583924; CAC31143.1; -; Genomic_DNA.
DR   PIR; G87182; G87182.
DR   RefSeq; NP_302433.1; NC_002677.1.
DR   RefSeq; WP_010908753.1; NC_002677.1.
DR   AlphaFoldDB; Q50047; -.
DR   SMR; Q50047; -.
DR   STRING; 272631.ML2188; -.
DR   EnsemblBacteria; CAC31143; CAC31143; CAC31143.
DR   KEGG; mle:ML2188; -.
DR   PATRIC; fig|272631.5.peg.4150; -.
DR   Leproma; ML2188; -.
DR   eggNOG; COG0704; Bacteria.
DR   HOGENOM; CLU_078518_1_0_11; -.
DR   OMA; WKHGIET; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0030643; P:cellular phosphate ion homeostasis; IEA:InterPro.
DR   GO; GO:0045936; P:negative regulation of phosphate metabolic process; ISS:UniProtKB.
DR   GO; GO:2000186; P:negative regulation of phosphate transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.220; -; 1.
DR   InterPro; IPR028366; P_transport_PhoU.
DR   InterPro; IPR038078; PhoU-like_sf.
DR   InterPro; IPR026022; PhoU_dom.
DR   PANTHER; PTHR42930; PTHR42930; 1.
DR   Pfam; PF01895; PhoU; 2.
DR   PIRSF; PIRSF003107; PhoU; 1.
DR   TIGRFAMs; TIGR02135; phoU_full; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphate transport; Reference proteome; Transport.
FT   CHAIN           1..222
FT                   /note="Phosphate-specific transport system accessory
FT                   protein PhoU homolog 1"
FT                   /id="PRO_0000155170"
SQ   SEQUENCE   222 AA;  24518 MW;  845612D9F4E665EF CRC64;
     MRTAYHEQLS ELSERLSEMC GLAGIAMERA TQALLQADLM LAEQVITDHE KIATRSARAE
     ESAFVLLALQ APVAGDLRAI VSAIQMVAAI DRMGALALHV AKTARRRHPQ HVLPEEVNGY
     FAEIGRVAVE LGNGAQEVVL SRDPEKAAQI REKDDAMDEL HRHLFSVLMD REWKHGVAAA
     VDVTLLGRFY ERFADHAVEV ARRVIFQATG SFPEDDTVPG SR