ID   PHOU1_MYCTU             Reviewed;         221 AA.
AC   P9WI97; L0TEX6; O07167; P65718;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Phosphate-specific transport system accessory protein PhoU homolog 1;
DE            Short=Pst system accessory protein PhoU homolog 1;
GN   Name=phoU1; Synonyms=phoY1; OrderedLocusNames=Rv3301c;
GN   ORFNames=MTCI418A.03c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Plays a role in the regulation of phosphate uptake. In this
CC       role, it may bind, possibly as a chaperone, to PhoR, PhoP or a PhoR-
CC       PhoP complex to promote dephosphorylation of phospho-PhoP, or inhibit
CC       formation of the PhoR-PhoP transitory complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PhoU family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP46120.1; -; Genomic_DNA.
DR   PIR; G70533; G70533.
DR   RefSeq; NP_217818.1; NC_000962.3.
DR   RefSeq; WP_003417216.1; NZ_NVQJ01000003.1.
DR   AlphaFoldDB; P9WI97; -.
DR   SMR; P9WI97; -.
DR   STRING; 83332.Rv3301c; -.
DR   PaxDb; P9WI97; -.
DR   DNASU; 887212; -.
DR   GeneID; 45427296; -.
DR   GeneID; 887212; -.
DR   KEGG; mtu:Rv3301c; -.
DR   TubercuList; Rv3301c; -.
DR   eggNOG; COG0704; Bacteria.
DR   OMA; ENDHQIN; -.
DR   PhylomeDB; P9WI97; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0030643; P:cellular phosphate ion homeostasis; IEA:InterPro.
DR   GO; GO:0045936; P:negative regulation of phosphate metabolic process; ISS:UniProtKB.
DR   GO; GO:2000186; P:negative regulation of phosphate transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.220; -; 1.
DR   InterPro; IPR028366; P_transport_PhoU.
DR   InterPro; IPR038078; PhoU-like_sf.
DR   InterPro; IPR026022; PhoU_dom.
DR   PANTHER; PTHR42930; PTHR42930; 1.
DR   Pfam; PF01895; PhoU; 2.
DR   PIRSF; PIRSF003107; PhoU; 1.
DR   TIGRFAMs; TIGR02135; phoU_full; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Phosphate transport; Reference proteome; Transport.
FT   CHAIN           1..221
FT                   /note="Phosphate-specific transport system accessory
FT                   protein PhoU homolog 1"
FT                   /id="PRO_0000155171"
SQ   SEQUENCE   221 AA;  24827 MW;  94CEAA23E31BCD32 CRC64;
     MRTVYHQRLT ELAGRLGEMC SLAGIAMKRA TQALLEADIG AAEQVIRDHE RIVAMRAQVE
     KEAFALLALQ HPVAGELREI FSAVQIIADT ERMGALAVHI AKITRREYPN QVLPEEVRNC
     FADMAKVAIA LGDSARQVLV NRDPQEAAQL HDRDDAMDDL HRHLLSVLID REWRHGVRVG
     VETALLGRFF ERFADHAVEV GRRVIFMVTG VLPTEDEIST Y