ID   PHOU2_MYCBO             Reviewed;         213 AA.
AC   P65721; A0A1R3XXH7; O53833; X2BG89;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Phosphate-specific transport system accessory protein PhoU homolog 2;
DE            Short=Pst system accessory protein PhoU homolog 2;
GN   Name=phoU2; Synonyms=phoY2; OrderedLocusNames=BQ2027_MB0844C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Plays a role in the regulation of phosphate uptake. In this
CC       role, it may bind, possibly as a chaperone, to PhoR, PhoP or a PhoR-
CC       PhoP complex to promote dephosphorylation of phospho-PhoP, or inhibit
CC       formation of the PhoR-PhoP transitory complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PhoU family. {ECO:0000305}.
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DR   EMBL; LT708304; SIT99443.1; -; Genomic_DNA.
DR   RefSeq; NP_854502.1; NC_002945.3.
DR   RefSeq; WP_003404314.1; NC_002945.4.
DR   AlphaFoldDB; P65721; -.
DR   SMR; P65721; -.
DR   EnsemblBacteria; SIT99443; SIT99443; BQ2027_MB0844C.
DR   GeneID; 45424784; -.
DR   PATRIC; fig|233413.5.peg.917; -.
DR   OMA; WKHGIET; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0030643; P:cellular phosphate ion homeostasis; IEA:InterPro.
DR   GO; GO:0045936; P:negative regulation of phosphate metabolic process; ISS:UniProtKB.
DR   GO; GO:2000186; P:negative regulation of phosphate transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.220; -; 1.
DR   InterPro; IPR028366; P_transport_PhoU.
DR   InterPro; IPR038078; PhoU-like_sf.
DR   InterPro; IPR026022; PhoU_dom.
DR   PANTHER; PTHR42930; PTHR42930; 1.
DR   Pfam; PF01895; PhoU; 2.
DR   PIRSF; PIRSF003107; PhoU; 1.
DR   TIGRFAMs; TIGR02135; phoU_full; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphate transport; Transport.
FT   CHAIN           1..213
FT                   /note="Phosphate-specific transport system accessory
FT                   protein PhoU homolog 2"
FT                   /id="PRO_0000155174"
SQ   SEQUENCE   213 AA;  23514 MW;  D2EDD9A9968AEA19 CRC64;
     MRTAYHEQLS ELSERLGEMC GLAGIAMERA TQALLQADLV LAEQVISDHE KIATLSARAE
     ESAFVLLALQ APVAGDLRAI VSAIQMVADI DRMGALALHV AKIARRRHPQ HALPEEVNGY
     FAEMGRVAVE LGNSAQEVVL SHDPEKAAQI REEDDAMDDL HRHLFTVLMD REWKHGVAAA
     VDVTLLSRFY ERFADHAVEV ARRVIFQATG AFP