ID   PHOU2_MYCTO             Reviewed;         213 AA.
AC   P9WI94; L0T6J6; O53833; P65720;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Phosphate-specific transport system accessory protein PhoU homolog 2;
DE            Short=Pst system accessory protein PhoU homolog 2;
GN   Name=phoU2; Synonyms=phoY2; OrderedLocusNames=MT0843;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Plays a role in the regulation of phosphate uptake. In this
CC       role, it may bind, possibly as a chaperone, to PhoR, PhoP or a PhoR-
CC       PhoP complex to promote dephosphorylation of phospho-PhoP, or inhibit
CC       formation of the PhoR-PhoP transitory complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PhoU family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK45085.1; -; Genomic_DNA.
DR   PIR; E70810; E70810.
DR   RefSeq; WP_003404314.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WI94; -.
DR   SMR; P9WI94; -.
DR   EnsemblBacteria; AAK45085; AAK45085; MT0843.
DR   GeneID; 45424784; -.
DR   KEGG; mtc:MT0843; -.
DR   PATRIC; fig|83331.31.peg.902; -.
DR   HOGENOM; CLU_078518_1_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0030643; P:cellular phosphate ion homeostasis; IEA:InterPro.
DR   GO; GO:0045936; P:negative regulation of phosphate metabolic process; ISS:UniProtKB.
DR   GO; GO:2000186; P:negative regulation of phosphate transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.220; -; 1.
DR   InterPro; IPR028366; P_transport_PhoU.
DR   InterPro; IPR038078; PhoU-like_sf.
DR   InterPro; IPR026022; PhoU_dom.
DR   PANTHER; PTHR42930; PTHR42930; 1.
DR   Pfam; PF01895; PhoU; 2.
DR   PIRSF; PIRSF003107; PhoU; 1.
DR   TIGRFAMs; TIGR02135; phoU_full; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Pharmaceutical; Phosphate transport; Transport.
FT   CHAIN           1..213
FT                   /note="Phosphate-specific transport system accessory
FT                   protein PhoU homolog 2"
FT                   /id="PRO_0000428046"
SQ   SEQUENCE   213 AA;  23514 MW;  D2EDD9A9968AEA19 CRC64;
     MRTAYHEQLS ELSERLGEMC GLAGIAMERA TQALLQADLV LAEQVISDHE KIATLSARAE
     ESAFVLLALQ APVAGDLRAI VSAIQMVADI DRMGALALHV AKIARRRHPQ HALPEEVNGY
     FAEMGRVAVE LGNSAQEVVL SHDPEKAAQI REEDDAMDDL HRHLFTVLMD REWKHGVAAA
     VDVTLLSRFY ERFADHAVEV ARRVIFQATG AFP