PHOU2_THEMA
ID PHOU2_THEMA Reviewed; 235 AA.
AC Q9X256;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=Phosphate-specific transport system accessory protein PhoU homolog 2;
DE Short=Pst system accessory protein PhoU homolog 2;
DE AltName: Full=Phosphate uptake regulator PhoU homolog 2;
GN Name=phoU2; OrderedLocusNames=TM_1734;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH IRON IONS AND NICKEL
RP ION.
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=15716271; DOI=10.1074/jbc.m414117200;
RA Liu J., Lou Y., Yokota H., Adams P.D., Kim R., Kim S.H.;
RT "Crystal structure of a PhoU protein homologue: a new class of
RT metalloprotein containing multinuclear iron clusters.";
RL J. Biol. Chem. 280:15960-15966(2005).
CC -!- FUNCTION: Plays a role in the regulation of phosphate uptake.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PhoU family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE000512; AAD36799.1; -; Genomic_DNA.
DR PIR; E72217; E72217.
DR RefSeq; NP_229532.1; NC_000853.1.
DR RefSeq; WP_004082252.1; NZ_CP011107.1.
DR PDB; 1SUM; X-ray; 2.00 A; B=1-235.
DR PDBsum; 1SUM; -.
DR AlphaFoldDB; Q9X256; -.
DR SMR; Q9X256; -.
DR STRING; 243274.THEMA_05565; -.
DR EnsemblBacteria; AAD36799; AAD36799; TM_1734.
DR KEGG; tma:TM1734; -.
DR eggNOG; COG0704; Bacteria.
DR InParanoid; Q9X256; -.
DR OMA; ENDHQIN; -.
DR OrthoDB; 1648549at2; -.
DR EvolutionaryTrace; Q9X256; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0030643; P:cellular phosphate ion homeostasis; IEA:InterPro.
DR GO; GO:0045936; P:negative regulation of phosphate metabolic process; ISS:UniProtKB.
DR GO; GO:2000186; P:negative regulation of phosphate transmembrane transport; ISS:UniProtKB.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.220; -; 2.
DR InterPro; IPR028366; P_transport_PhoU.
DR InterPro; IPR038078; PhoU-like_sf.
DR InterPro; IPR026022; PhoU_dom.
DR PANTHER; PTHR42930; PTHR42930; 1.
DR Pfam; PF01895; PhoU; 2.
DR PIRSF; PIRSF003107; PhoU; 1.
DR TIGRFAMs; TIGR02135; phoU_full; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Phosphate transport; Reference proteome;
KW Transport.
FT CHAIN 1..235
FT /note="Phosphate-specific transport system accessory
FT protein PhoU homolog 2"
FT /id="PRO_0000155183"
FT HELIX 5..36
FT /evidence="ECO:0007829|PDB:1SUM"
FT HELIX 39..70
FT /evidence="ECO:0007829|PDB:1SUM"
FT HELIX 75..107
FT /evidence="ECO:0007829|PDB:1SUM"
FT HELIX 118..138
FT /evidence="ECO:0007829|PDB:1SUM"
FT HELIX 142..145
FT /evidence="ECO:0007829|PDB:1SUM"
FT HELIX 147..172
FT /evidence="ECO:0007829|PDB:1SUM"
FT HELIX 174..176
FT /evidence="ECO:0007829|PDB:1SUM"
FT HELIX 177..209
FT /evidence="ECO:0007829|PDB:1SUM"
FT STRAND 213..216
FT /evidence="ECO:0007829|PDB:1SUM"
FT STRAND 219..222
FT /evidence="ECO:0007829|PDB:1SUM"
SQ SEQUENCE 235 AA; 26821 MW; 48558C71B710D831 CRC64;
MNRLLNEKVE EFKKGVLKAG WFIEKMFRNS ISSLVERNES LAREVIADEE VVDQMEVEIQ
EKAMEVLGLF SPIGKPLLTV TAGIRVAELI ENIADKCHDI AKNVLELMEE PPLKPLEDIP
AMANQTSEML KFALRMFADV NVEKSFEVCR MDSKVDDLYE KVREELLLYM MESPKYVKRA
LLLLEIAGNI EIIADYATNI VEVSVYMVQG EAYKCYHDEL LLFKKSGGVL FESSD