ID   PHOU_CLOAB              Reviewed;         219 AA.
AC   Q97ID9;
DT   06-FEB-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Phosphate-specific transport system accessory protein PhoU homolog {ECO:0000250|UniProtKB:P0A9K7};
DE            Short=Pst system accessory protein PhoU homolog {ECO:0000250|UniProtKB:P0A9K7};
DE   AltName: Full=Phosphate uptake regulator {ECO:0000312|EMBL:AAK79675.1};
GN   Name=phoU {ECO:0000312|EMBL:AAK79675.1}; OrderedLocusNames=CA_C1709;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1] {ECO:0000312|EMBL:AAK79675.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
RN   [2] {ECO:0000305}
RP   OPERON STRUCTURE, AND INDUCTION.
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787
RC   {ECO:0000269|PubMed:16855236};
RX   PubMed=16855236; DOI=10.1128/jb.00491-06;
RA   Fischer R.J., Oehmcke S., Meyer U., Mix M., Schwarz K., Fiedler T.,
RA   Bahl H.;
RT   "Transcription of the pst operon of Clostridium acetobutylicum is dependent
RT   on phosphate concentration and pH.";
RL   J. Bacteriol. 188:5469-5478(2006).
CC   -!- FUNCTION: Plays a role in the regulation of phosphate uptake (By
CC       similarity). Encoded together with proteins of the phosphate-specific
CC       transport (Pst) system in the polycistronic pstSCAB-phoU operon.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:O67053}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P0A9K7}.
CC   -!- INDUCTION: By phosphate limitation. {ECO:0000269|PubMed:16855236}.
CC   -!- SIMILARITY: Belongs to the PhoU family. {ECO:0000255}.
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DR   EMBL; AE001437; AAK79675.1; -; Genomic_DNA.
DR   PIR; H97110; H97110.
DR   RefSeq; NP_348335.1; NC_003030.1.
DR   RefSeq; WP_010965016.1; NC_003030.1.
DR   AlphaFoldDB; Q97ID9; -.
DR   SMR; Q97ID9; -.
DR   STRING; 272562.CA_C1709; -.
DR   PRIDE; Q97ID9; -.
DR   EnsemblBacteria; AAK79675; AAK79675; CA_C1709.
DR   GeneID; 44998204; -.
DR   KEGG; cac:CA_C1709; -.
DR   PATRIC; fig|272562.8.peg.1911; -.
DR   eggNOG; COG0704; Bacteria.
DR   HOGENOM; CLU_078518_3_0_9; -.
DR   OMA; WKHGIET; -.
DR   OrthoDB; 1648549at2; -.
DR   Proteomes; UP000000814; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0030643; P:cellular phosphate ion homeostasis; IEA:InterPro.
DR   GO; GO:0045936; P:negative regulation of phosphate metabolic process; ISS:UniProtKB.
DR   GO; GO:2000186; P:negative regulation of phosphate transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0019220; P:regulation of phosphate metabolic process; IGC:UniProtKB.
DR   Gene3D; 1.20.58.220; -; 1.
DR   InterPro; IPR028366; P_transport_PhoU.
DR   InterPro; IPR038078; PhoU-like_sf.
DR   InterPro; IPR026022; PhoU_dom.
DR   PANTHER; PTHR42930; PTHR42930; 1.
DR   Pfam; PF01895; PhoU; 2.
DR   PIRSF; PIRSF003107; PhoU; 1.
DR   TIGRFAMs; TIGR02135; phoU_full; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphate transport; Reference proteome; Transport.
FT   CHAIN           1..219
FT                   /note="Phosphate-specific transport system accessory
FT                   protein PhoU homolog"
FT                   /id="PRO_0000420871"
SQ   SEQUENCE   219 AA;  25566 MW;  7CFA92B616758A3F CRC64;
     MTRKIFESDL EELHSELLRM GSMAEKQIYD CMEALEKQDE NMAEVIIKKD DIIDDMQKEI
     ENKVIRLIAM QQPIVAEDLR NIFTTVKIVT DLERLGDHAV DIAKAIKRLN GEKHHDIVKE
     IWNMGNKVKS MIKDSLDAYV ERNLDKAYEV CKRDDDVDSL YKRIFNELLN IMSEDKSKVN
     QLTQFLFVCK YLERIGDRTT NVCESTIYLI TGKQVDLND