ID   PHOU_STRR6              Reviewed;         216 AA.
AC   P0A3Y8; Q9X4T4;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Phosphate-specific transport system accessory protein PhoU homolog;
DE            Short=Pst system accessory protein PhoU homolog;
GN   Name=phoU; OrderedLocusNames=spr1899;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=R6x;
RX   PubMed=9973337; DOI=10.1128/jb.181.4.1126-1133.1999;
RA   Novak R., Cauwels A., Charpentier E., Tuomanen E.;
RT   "Identification of a Streptococcus pneumoniae gene locus encoding proteins
RT   of an ABC phosphate transporter and a two-component regulatory system.";
RL   J. Bacteriol. 181:1126-1133(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- FUNCTION: Plays a role in the regulation of phosphate uptake.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PhoU family. {ECO:0000305}.
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DR   EMBL; AF118229; AAD22042.1; -; Genomic_DNA.
DR   EMBL; AE007317; AAL00701.1; -; Genomic_DNA.
DR   PIR; H98108; H98108.
DR   RefSeq; NP_359490.1; NC_003098.1.
DR   RefSeq; WP_001245781.1; NC_003098.1.
DR   AlphaFoldDB; P0A3Y8; -.
DR   SMR; P0A3Y8; -.
DR   STRING; 171101.spr1899; -.
DR   EnsemblBacteria; AAL00701; AAL00701; spr1899.
DR   GeneID; 60232703; -.
DR   GeneID; 66807168; -.
DR   KEGG; spr:spr1899; -.
DR   PATRIC; fig|171101.6.peg.2048; -.
DR   eggNOG; COG0704; Bacteria.
DR   HOGENOM; CLU_078518_3_0_9; -.
DR   OMA; DAMYNSL; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0030643; P:cellular phosphate ion homeostasis; IEA:InterPro.
DR   GO; GO:0045936; P:negative regulation of phosphate metabolic process; ISS:UniProtKB.
DR   GO; GO:2000186; P:negative regulation of phosphate transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.220; -; 1.
DR   InterPro; IPR028366; P_transport_PhoU.
DR   InterPro; IPR038078; PhoU-like_sf.
DR   InterPro; IPR026022; PhoU_dom.
DR   PANTHER; PTHR42930; PTHR42930; 1.
DR   Pfam; PF01895; PhoU; 2.
DR   PIRSF; PIRSF003107; PhoU; 1.
DR   TIGRFAMs; TIGR02135; phoU_full; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphate transport; Reference proteome; Transport.
FT   CHAIN           1..216
FT                   /note="Phosphate-specific transport system accessory
FT                   protein PhoU homolog"
FT                   /id="PRO_0000155180"
SQ   SEQUENCE   216 AA;  24192 MW;  58E2C3ABBE653B4B CRC64;
     MRNQFDLELH ELEQSFLGLG QLVLETASKA LLALASKDKE MAELIINKDH AINQGQSAIE
     LTCARLLALQ QPQVSDLRFV ISIMSSCSDL ERMGDHMAGI AKAVLQLKEN QLAPDEEQLH
     QMGKLSLSML ADLLVAFPLH QASKAISIAQ KDEQIDQYYY ALSKEIIGLM KDQETSIPNG
     TQYLYIIGHL ERFADYIANI CERLVYLETG ELVDLN