PHOX3_ARATH
ID PHOX3_ARATH Reviewed; 809 AA.
AC F4K487;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Protein PHOX3 {ECO:0000303|PubMed:20856808};
GN Name=PHOX3 {ECO:0000303|PubMed:20856808};
GN OrderedLocusNames=At5g20360 {ECO:0000312|Araport:AT5G20360};
GN ORFNames=F5O24.250 {ECO:0000312|EMBL:AED92835.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [4]
RP GENE FAMILY, NOMENCLATURE, FUNCTION, AND INDUCTION.
RX PubMed=20856808; DOI=10.1371/journal.pone.0012761;
RA Prasad B.D., Goel S., Krishna P.;
RT "In silico identification of carboxylate clamp type tetratricopeptide
RT repeat proteins in Arabidopsis and rice as putative co-chaperones of
RT Hsp90/Hsp70.";
RL PLoS ONE 5:E12761-E12761(2010).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28096376; DOI=10.1073/pnas.1620577114;
RA Kurth E.G., Peremyslov V.V., Turner H.L., Makarova K.S., Iranzo J.,
RA Mekhedov S.L., Koonin E.V., Dolja V.V.;
RT "Myosin-driven transport network in plants.";
RL Proc. Natl. Acad. Sci. U.S.A. 114:E1385-E1394(2017).
CC -!- FUNCTION: Carboxylate clamp type tetratricopeptide repeat protein that
CC may act as a potential Hsp90/Hsp70 co-chaperone (PubMed:20856808).
CC Contributes to polar growth of root hairs (PubMed:28096376).
CC {ECO:0000269|PubMed:28096376, ECO:0000305|PubMed:20856808}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. {ECO:0000305};
CC Name=1;
CC IsoId=F4K487-1; Sequence=Displayed;
CC -!- INDUCTION: Up-regulated by abscisic acid treatment, and by cold and
CC salt stress. {ECO:0000269|PubMed:20856808}.
CC -!- DISRUPTION PHENOTYPE: Phox1, phox3 and phox4 triple mutants and phox1,
CC phox2, phox3 and phox4 quadruple mutants show a 70% reduction in root
CC hair growth (PubMed:28096376). {ECO:0000269|PubMed:28096376}.
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DR EMBL; AF296825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED92835.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM71141.1; -; Genomic_DNA.
DR RefSeq; NP_001332690.1; NM_001343653.1. [F4K487-1]
DR RefSeq; NP_197536.1; NM_122043.3. [F4K487-1]
DR AlphaFoldDB; F4K487; -.
DR SMR; F4K487; -.
DR STRING; 3702.AT5G20360.1; -.
DR iPTMnet; F4K487; -.
DR PaxDb; F4K487; -.
DR PRIDE; F4K487; -.
DR ProteomicsDB; 234720; -. [F4K487-1]
DR EnsemblPlants; AT5G20360.1; AT5G20360.1; AT5G20360. [F4K487-1]
DR EnsemblPlants; AT5G20360.2; AT5G20360.2; AT5G20360. [F4K487-1]
DR GeneID; 832158; -.
DR Gramene; AT5G20360.1; AT5G20360.1; AT5G20360. [F4K487-1]
DR Gramene; AT5G20360.2; AT5G20360.2; AT5G20360. [F4K487-1]
DR KEGG; ath:AT5G20360; -.
DR Araport; AT5G20360; -.
DR TAIR; locus:2149174; AT5G20360.
DR eggNOG; KOG4151; Eukaryota.
DR HOGENOM; CLU_014258_0_0_1; -.
DR InParanoid; F4K487; -.
DR OrthoDB; 380896at2759; -.
DR PhylomeDB; F4K487; -.
DR PRO; PR:F4K487; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4K487; baseline and differential.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR044517; PHOX1-4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46183; PTHR46183; 1.
DR Pfam; PF00564; PB1; 1.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50005; TPR; 2.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome; Repeat;
KW TPR repeat.
FT CHAIN 1..809
FT /note="Protein PHOX3"
FT /id="PRO_0000440021"
FT REPEAT 126..159
FT /note="TPR 1"
FT /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT ProRule:PRU00339"
FT REPEAT 164..199
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT REPEAT 200..233
FT /note="TPR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 235..265
FT /note="TPR 4"
FT /evidence="ECO:0000255"
FT REPEAT 274..311
FT /note="TPR 5"
FT /evidence="ECO:0000255"
FT DOMAIN 359..438
FT /note="PB1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT REPEAT 508..541
FT /note="TPR 6"
FT /evidence="ECO:0000255"
FT REPEAT 563..597
FT /note="TPR 7"
FT /evidence="ECO:0000255"
FT REPEAT 615..648
FT /note="TPR 8"
FT /evidence="ECO:0000255"
FT REPEAT 709..741
FT /note="TPR 9"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 298
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19376835"
SQ SEQUENCE 809 AA; 91522 MW; 749615589D8126F5 CRC64;
MEKQNEEIST DDAETSQSQL VDDSKVETLD DCVSKVETLD DCVSKVETLD DCVSKAETLA
DCVSKVETLD DCVSKVKTLD DCVSKVENLD DCVPKVETLD DCVPKVETLD DCVSEVETLD
DCVSKAQGLK EEGNKLFQKR DYDGAMFKYG EAIKILPKDH VEVSHVRANV ASCYMQLEPG
EFAKAIHECD LALSVTPDHN KALLKRARCY EALNKLDLAL RDVCMVSKLD PKNPMASEIV
EKLKRTLESK GLRINNSVIE LPPDYVEPVG ASPAALWAKL GKVRVKKTKK SNQVEEKSEG
EGEDVEPEKK NNVLAEKGKE KIKMKVKGKQ SDKRSDTSKE QEKVIIEEEL LVIGVEDVNK
DVKFVYSDDI RLAELPINCT LFKLREVVHE RFPSLRAVHI KYRDQEGDLV TITTDEELRM
SEVSSRSQGT MRFYVVEVSP EQDPFFGRLV EMKKLKITAD SFKAKVNGRG GCKVEDWMIE
FAHLFKIQAR IDSDRCLNLQ ELGMKLNSEA MEEVVTSDAA QGPFDRAAQQ FQEVAARSLL
NLGYVHMSGA RKRLSLLQGV SGESVSEQVK TAYECAKKEH ANAKEKYEEA MKIKPECFEV
FLALGLQQFE EARLSWYYVL VSHLDLKTWP YADVVQFYQS AESNIKKSME VLENLETGKE
SEPSQAGKTD CLTHEKDLGS STQNNPAKEA GRLKSWIDIL LCAVLYERSI MEYKLDQPFW
RESLEAAMEK FELAGTCKDD VVEIISEDYV AGNTLRDIRF HMEEIIQIFD EIYEAKHWTN
GIPSDQLEEI LKRRAENIFH VPNIAIQRG
