PHOX4_ARATH
ID PHOX4_ARATH Reviewed; 782 AA.
AC F4JTI1; O49385; Q56Y06;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 1.
DT 03-AUG-2022, entry version 25.
DE RecName: Full=Protein PHOX4 {ECO:0000303|PubMed:20856808};
GN Name=PHOX4 {ECO:0000303|PubMed:20856808};
GN OrderedLocusNames=At4g32070 {ECO:0000312|Araport:AT4G32070};
GN ORFNames=F10N7.120 {ECO:0000312|EMBL:AEE86001.2};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-259.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, NOMENCLATURE, FUNCTION, AND INDUCTION.
RX PubMed=20856808; DOI=10.1371/journal.pone.0012761;
RA Prasad B.D., Goel S., Krishna P.;
RT "In silico identification of carboxylate clamp type tetratricopeptide
RT repeat proteins in Arabidopsis and rice as putative co-chaperones of
RT Hsp90/Hsp70.";
RL PLoS ONE 5:E12761-E12761(2010).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=22025705; DOI=10.1073/pnas.1106706108;
RA Yang Y., Sage T.L., Liu Y., Ahmad T.R., Marshall W.F., Shiu S.H.,
RA Froehlich J.E., Imre K.M., Osteryoung K.W.;
RT "CLUMPED CHLOROPLASTS 1 is required for plastid separation in
RT Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:18530-18535(2011).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28096376; DOI=10.1073/pnas.1620577114;
RA Kurth E.G., Peremyslov V.V., Turner H.L., Makarova K.S., Iranzo J.,
RA Mekhedov S.L., Koonin E.V., Dolja V.V.;
RT "Myosin-driven transport network in plants.";
RL Proc. Natl. Acad. Sci. U.S.A. 114:E1385-E1394(2017).
CC -!- FUNCTION: Carboxylate clamp-type tetratricopeptide repeat protein that
CC may act as a potential Hsp90/Hsp70 co-chaperone (PubMed:20856808).
CC Contributes to polar growth of root hairs (PubMed:28096376).
CC {ECO:0000269|PubMed:28096376, ECO:0000305|PubMed:20856808}.
CC -!- INDUCTION: Up-regulated by abscisic acid treatment, and by cold,
CC osmotic and salt stress. {ECO:0000269|PubMed:20856808}.
CC -!- DISRUPTION PHENOTYPE: No clumped-chloroplasts phenotype
CC (PubMed:22025705). Phox1 and phox4 double mutants show no clumped-
CC chloroplasts phenotype, but a 46% reduction in root hair growth
CC (PubMed:22025705, PubMed:28096376). Phox1, phox3 and phox4 triple
CC mutants and phox1, phox2, phox3 and phox4 quadruple mutants show a 70%
CC reduction in root hair growth (PubMed:28096376).
CC {ECO:0000269|PubMed:22025705, ECO:0000269|PubMed:28096376}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA16582.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79925.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL021636; CAA16582.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161580; CAB79925.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86001.2; -; Genomic_DNA.
DR EMBL; CP002687; ANM67744.1; -; Genomic_DNA.
DR EMBL; AK221517; BAD94792.1; -; mRNA.
DR PIR; T04638; T04638.
DR RefSeq; NP_001320111.1; NM_001342126.1.
DR RefSeq; NP_001329553.1; NM_001342127.1.
DR AlphaFoldDB; F4JTI1; -.
DR SMR; F4JTI1; -.
DR IntAct; F4JTI1; 4.
DR STRING; 3702.AT4G32070.1; -.
DR iPTMnet; F4JTI1; -.
DR PRIDE; F4JTI1; -.
DR ProteomicsDB; 236678; -.
DR EnsemblPlants; AT4G32070.1; AT4G32070.1; AT4G32070.
DR EnsemblPlants; AT4G32070.2; AT4G32070.2; AT4G32070.
DR GeneID; 829338; -.
DR Gramene; AT4G32070.1; AT4G32070.1; AT4G32070.
DR Gramene; AT4G32070.2; AT4G32070.2; AT4G32070.
DR KEGG; ath:AT4G32070; -.
DR Araport; AT4G32070; -.
DR TAIR; locus:2116677; AT4G32070.
DR eggNOG; KOG4151; Eukaryota.
DR OMA; SEMYERF; -.
DR OrthoDB; 260600at2759; -.
DR PRO; PR:F4JTI1; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JTI1; baseline and differential.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR044517; PHOX1-4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46183; PTHR46183; 1.
DR Pfam; PF00564; PB1; 1.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..782
FT /note="Protein PHOX4"
FT /id="PRO_0000440022"
FT REPEAT 51..84
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 89..124
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT REPEAT 126..158
FT /note="TPR 3"
FT /evidence="ECO:0000255"
FT DOMAIN 317..396
FT /note="PB1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT REPEAT 444..478
FT /note="TPR 4"
FT /evidence="ECO:0000255"
FT REPEAT 532..565
FT /note="TPR 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 590..623
FT /note="TPR 6"
FT /evidence="ECO:0000255"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 782 AA; 87975 MW; F3A657014D449B68 CRC64;
MGKPTAKKKN PETPKDASGG GGGGGGKSGK TYHRSTSRVF DEDMEIFISR ALELKEEGNK
LFQKRDHEGA MLSFDKALKL LPKDHIDVAY LRTSMASCYM QMGLGEYPNA ISECNLALEA
SPRYSKALVR RSRCYEALNK LDYAFRDARI VLNMEPGNVS ANEIFDRVKK VLVDKGIDVD
EMEKDFVDVQ PVCAARLKKI VKERLRKSKK KKKSGGKDEE LKSPKVVVVD KGDEAEGRNK
PKEEKSDKSD IDGKIGGKRE EKKTSFKSDK GQKKKSGGNK AGEERKVEDK VVVMDKEVIA
SEIVDGGGSK KEGATVTRTI KLVHGDDIRW AQLPLDSTVR LVRDVIRDRF PALRGFLIKY
RDTEGDLVTI TTTDELRLAA STHDKLGSLR LYIAEVNPDQ EPTYDGMSNT ESTDKVSKRL
SSLADNGSVG EYVGSDKASG CFENWIFQFA QLFKNHVGFD SDSYVDLHDL GMKLYTEAME
DAVTGEDAQE LFQIAADKFQ EMGALALLNW GNVHMSKARK QVCIPEDASR EAIIEAVEAA
FVWTQNEYNK AAEKYEEAIK VKPDFYEALL ALGQEQFEHA KLCWYHALKS KVDLESEASQ
EVLKLYNKAE DSMERGMQIW EEMEECRLNG ISKLDKHKNM LRKLELDELF SEASEEETVE
QTANMSSQIN LLWGSLLYER SIVEYKLGLP TWDECLEVAV EKFELAGASA TDIAVMVKNH
CSSESALEGM GFKIDEIVQA WNEMYDAKRW QMGVPSFRLE PMFRRRAPKL HDILENVFSG
PV
