PHP3_CAEEL
ID PHP3_CAEEL Reviewed; 275 AA.
AC Q9XW88; Q9U9C3;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Homeobox protein php-3 {ECO:0000305};
DE AltName: Full=Posterior Hox protein paralog 3 {ECO:0000303|PubMed:10781051};
GN Name=php-3 {ECO:0000312|WormBase:Y75B8A.1};
GN ORFNames=Y75B8A.1 {ECO:0000312|WormBase:Y75B8A.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:AAD48876.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=Bristol N2 {ECO:0000312|EMBL:AAD48876.1};
RX PubMed=10781051; DOI=10.1073/pnas.97.9.4499;
RA Van Auken K., Weaver D.C., Edgar L.G., Wood W.B.;
RT "Caenorhabditis elegans embryonic axial patterning requires two recently
RT discovered posterior-group Hox genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:4499-4503(2000).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21408209; DOI=10.1371/journal.pgen.1002010;
RA Nelson M.D., Zhou E., Kiontke K., Fradin H., Maldonado G., Martin D.,
RA Shah K., Fitch D.H.;
RT "A bow-tie genetic architecture for morphogenesis suggested by a genome-
RT wide RNAi screen in Caenorhabditis elegans.";
RL PLoS Genet. 7:E1002010-E1002010(2011).
CC -!- FUNCTION: Probable transcription factor, involved in posterior
CC embryonic patterning, morphogenetic movements of the posterior
CC hypodermis, and cell fate specification (PubMed:10781051,
CC PubMed:21408209). May regulate expression of transcription factor dmd-3
CC (PubMed:21408209). {ECO:0000269|PubMed:10781051,
CC ECO:0000269|PubMed:21408209}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|RuleBase:RU000682}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown in adults has no effect
CC on their F1 progeny, but increases the frequency of posterior
CC morphological abnormalities on a homeobox nob-1 mutant background
CC (PubMed:10781051). However, RNAi-mediated knockdown in L1 larvae causes
CC defects in tail tip morphogenesis, which are exacerbated on a nob-1
CC mutant background (PubMed:21408209). {ECO:0000269|PubMed:10781051,
CC ECO:0000269|PubMed:21408209}.
CC -!- SIMILARITY: Belongs to the abd-b homeobox family. {ECO:0000305}.
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DR EMBL; AF172092; AAD48876.1; -; mRNA.
DR EMBL; BX284603; CAA22081.2; -; Genomic_DNA.
DR PIR; T27381; T27381.
DR RefSeq; NP_499573.1; NM_067172.3.
DR AlphaFoldDB; Q9XW88; -.
DR SMR; Q9XW88; -.
DR DIP; DIP-26245N; -.
DR IntAct; Q9XW88; 21.
DR STRING; 6239.Y75B8A.1; -.
DR EPD; Q9XW88; -.
DR PaxDb; Q9XW88; -.
DR EnsemblMetazoa; Y75B8A.1.1; Y75B8A.1.1; WBGene00004024.
DR GeneID; 176640; -.
DR KEGG; cel:CELE_Y75B8A.1; -.
DR UCSC; Y75B8A.1; c. elegans.
DR CTD; 176640; -.
DR WormBase; Y75B8A.1; CE28148; WBGene00004024; php-3.
DR eggNOG; KOG0487; Eukaryota.
DR GeneTree; ENSGT00940000168206; -.
DR HOGENOM; CLU_1190784_0_0_1; -.
DR InParanoid; Q9XW88; -.
DR OMA; RWELAKY; -.
DR OrthoDB; 976319at2759; -.
DR SignaLink; Q9XW88; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00004024; Expressed in larva and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0110039; P:positive regulation of nematode male tail tip morphogenesis; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046333; HXA10/ABDB-like.
DR PANTHER; PTHR45874; PTHR45874; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..275
FT /note="Homeobox protein php-3"
FT /id="PRO_0000453032"
FT DNA_BIND 199..258
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 275 AA; 30538 MW; B1EAB24AB34F9A9E CRC64;
MISVMQQMMN NSNMPPPFVK SSDSHETHDE SPTSPFIKRS DSPATTSSAA AAAMQHNFWS
TRAAQLQQSV SGSSGVSSGS SSSASNNLSR TQADNHSERG SDTASSPQVA PLPTSSGMSM
PAAAAAGMYP FNAGRFPTEF NMMVNQSMYN DFYSNSLAAS SWPYSYPQQY PFANYSMPSL
DGNLNDGGQL EWTSSSHAMR KKRKPYTKAQ TLELEKEFLY NTYVSKQKRW ELAKYLHLTE
RQVKIWFQNR RMKDKKQKQR TSGDPTGMLM PPGLD
