ID   PHPA_PLACH              Reviewed;         441 AA.
AC   Q02752;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Acidic phosphoprotein;
DE   AltName: Full=50 kDa antigen;
DE   Flags: Precursor;
GN   Name=PCEMA1;
OS   Plasmodium chabaudi.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Vinckeia).
OX   NCBI_TaxID=5825;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=IP-PC1;
RX   PubMed=1475002; DOI=10.1016/0166-6851(92)90154-c;
RA   Deleersnijder W., Prasomsitti P., Tungpradubkul S., Hendrix D.,
RA   Hamers-Casterman C., Hamers R.;
RT   "Structure of a Plasmodium chabaudi acidic phosphoprotein that is
RT   associated with the host erythrocyte membrane.";
RL   Mol. Biochem. Parasitol. 56:59-68(1992).
CC   -!- FUNCTION: During infection, this phosphoprotein probably modulates the
CC       structure of the red cell membrane to the advantage of the parasite,
CC       although its precise function is not known.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein;
CC       Cytoplasmic side. Note=Peripheral membrane protein on the cytoplasmic
CC       face of the host erythrocyte membrane.
CC   -!- MISCELLANEOUS: Associated with the host red cell membrane throughout
CC       the entire erythrocytic cycle.
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DR   EMBL; M95789; AAA29732.1; -; Genomic_DNA.
DR   PIR; A48455; A48455.
DR   AlphaFoldDB; Q02752; -.
DR   VEuPathDB; PlasmoDB:PCHAS_1001500; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR010882; PCEMA1.
DR   Pfam; PF07418; PCEMA1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Membrane; Phosphoprotein; Repeat; Signal.
FT   SIGNAL          1..15
FT                   /note="Or 24"
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..441
FT                   /note="Acidic phosphoprotein"
FT                   /id="PRO_0000024575"
FT   REPEAT          186..193
FT                   /note="1-1"
FT   REPEAT          194..201
FT                   /note="1-2"
FT   REPEAT          202..209
FT                   /note="1-3"
FT   REPEAT          210..217
FT                   /note="1-4"
FT   REPEAT          218..225
FT                   /note="1-5"
FT   REPEAT          226..233
FT                   /note="1-6"
FT   REPEAT          234..241
FT                   /note="1-7"
FT   REPEAT          242..249
FT                   /note="1-8"
FT   REPEAT          250..257
FT                   /note="1-9"
FT   REPEAT          258..265
FT                   /note="1-10"
FT   REPEAT          266..273
FT                   /note="1-11"
FT   REPEAT          274..281
FT                   /note="1-12"
FT   REPEAT          282..289
FT                   /note="1-13"
FT   REPEAT          290..297
FT                   /note="1-14"
FT   REPEAT          298..305
FT                   /note="1-15"
FT   REPEAT          306..313
FT                   /note="1-16"
FT   REPEAT          353..360
FT                   /note="2-1"
FT   REPEAT          361..368
FT                   /note="2-2"
FT   REGION          186..313
FT                   /note="16 X 8 AA tandem repeats"
FT   REGION          232..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..370
FT                   /note="2 X 9 AA tandem repeats"
FT   COMPBIAS        288..309
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..340
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        345..374
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..411
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        21
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        112
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   441 AA;  49708 MW;  DB85E83E795EE7E5 CRC64;
     MKAISLGLIS SIIFSIVLAK NSSGSGSSTG CFGCFRKKPK KKILATEVAK PVKAPETADF
     DPKLPNLKFI EEFEPITIEG CKSRLHELDE PFVSETDGMI IDKVTGFSRR ENDSVLSGWY
     IRPYEEGYEN MIKVNFIPLR EYYKRMENRP PKQYDGPPPI PDMPQGYVPP KKEEIPVEQY
     VIQLSEEDPY LLQEEDALSL MEYDAETLNE GDAETLNEGD AETLNEYDAG TLNEEDAGTT
     NEAGEGTTNE EGEGAANEYD AETLNEYDAD TLNEYDAGTL NEYDAGTLNE EEGSTTNEAG
     EGTSNEAGEG TANDDEELDE EVASIFDDDE HADDLSLLDY DENSNENQEN VKKGNENEGE
     QKGNENEGEQ KGKKKKAKEK SKKKVKNKPT MTTKKKKKKE KKKKKKEKEK KKEKKVKVEV
     IMDHFSEMEK MMNNKIKHWN K