ID   A53R_VACCW              Reviewed;         103 AA.
AC   P24756; Q76ZM5;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   02-JUN-2021, entry version 75.
DE   RecName: Full=Truncated secreted TNF-receptor-like protein A53R;
GN   OrderedLocusNames=VACWR179; ORFNames=A53R;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2045793; DOI=10.1099/0022-1317-72-6-1349;
RA   Smith G.L., Chan Y.S., Howard S.T.;
RT   "Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the
RT   right inverted terminal repeat.";
RL   J. Gen. Virol. 72:1349-1376(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1846491; DOI=10.1016/0042-6822(91)90077-o;
RA   Howard S.T., Chan Y.S., Smith G.L.;
RT   "Vaccinia virus homologues of the Shope fibroma virus inverted terminal
RT   repeat proteins and a discontinuous ORF related to the tumor necrosis
RT   factor receptor family.";
RL   Virology 180:633-647(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- MISCELLANEOUS: The A53R protein from Western Reserve and Copenhagen
CC       strains are predicted to be inactive because of mutations that
CC       introduce stop codons or frameshifts when compared to other
CC       poxiviruses.
CC   -!- SIMILARITY: Belongs to the poxviridae A53R protein family.
CC       {ECO:0000305}.
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DR   EMBL; D11079; BAA01827.1; -; Genomic_DNA.
DR   EMBL; M58054; AAA48339.1; -; Genomic_DNA.
DR   EMBL; AY243312; AAO89458.1; -; Genomic_DNA.
DR   PIR; JQ1791; JQ1791.
DR   RefSeq; YP_233061.1; NC_006998.1.
DR   SMR; P24756; -.
DR   DNASU; 3707710; -.
DR   GeneID; 3707710; -.
DR   KEGG; vg:3707710; -.
DR   Proteomes; UP000000344; Genome.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   Pfam; PF00020; TNFR_c6; 1.
DR   SMART; SM00208; TNFR; 1.
DR   PROSITE; PS00652; TNFR_NGFR_1; 1.
DR   PROSITE; PS50050; TNFR_NGFR_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Late protein; Reference proteome; Repeat.
FT   CHAIN           1..103
FT                   /note="Truncated secreted TNF-receptor-like protein A53R"
FT                   /id="PRO_0000058941"
FT   REPEAT          36..73
FT                   /note="TNFR-Cys 1"
FT   REPEAT          74..103
FT                   /note="TNFR-Cys 2; truncated"
FT   DISULFID        37..50
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        51..64
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        54..72
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ   SEQUENCE   103 AA;  12001 MW;  87C3C68B5D1339CD CRC64;
     MIILKDGYKE FADCMYYFLH YYIGYGRYTY SATNGSCDKG EYLDKRHNQC CNRCPPGEFA
     KVRCNGNDNT KCERCPPHTY TTIPIILMDV INVENAQPDH LIR