ID   PHRH_BACSU              Reviewed;          57 AA.
AC   Q59HN7; O31508; P40771;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Phosphatase RapH inhibitor;
DE   AltName: Full=Phosphatase regulator H;
DE   Flags: Precursor;
GN   Name=phrH; OrderedLocusNames=BSU06839;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISRUPTION PHENOTYPE.
RC   STRAIN=168;
RX   PubMed=16553878; DOI=10.1111/j.1365-2958.2006.05059.x;
RA   Hayashi K., Kensuke T., Kobayashi K., Ogasawara N., Ogura M.;
RT   "Bacillus subtilis RghR (YvaN) represses rapG and rapH, which encode
RT   inhibitors of expression of the srfA operon.";
RL   Mol. Microbiol. 59:1714-1729(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44.
RX   PubMed=3145906; DOI=10.1016/0378-1119(88)90207-7;
RA   Smith H., de Jong A., Bron S., Venema G.;
RT   "Characterization of signal-sequence-coding regions selected from the
RT   Bacillus subtilis chromosome.";
RL   Gene 70:351-361(1988).
CC   -!- FUNCTION: Inhibitor of the activity of phosphatase RapH. May inhibit
CC       the rapH promoter after import into the cytoplasm.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Decreases expression from the aprE promoter.
CC       {ECO:0000269|PubMed:16553878}.
CC   -!- SIMILARITY: Belongs to the phr family. {ECO:0000305}.
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DR   EMBL; AB207815; BAD91218.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAX52580.1; -; Genomic_DNA.
DR   EMBL; M22915; AAA22831.1; -; Genomic_DNA.
DR   RefSeq; WP_003242557.1; NZ_JNCM01000032.1.
DR   RefSeq; YP_003097693.1; NC_000964.3.
DR   AlphaFoldDB; Q59HN7; -.
DR   STRING; 224308.BSU06839; -.
DR   EnsemblBacteria; CAX52580; CAX52580; BSU_06839.
DR   GeneID; 8303115; -.
DR   KEGG; bsu:BSU06839; -.
DR   PATRIC; fig|224308.179.peg.743; -.
DR   OMA; MMCLAVT; -.
DR   BioCyc; BSUB:BSU06839-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..57
FT                   /note="Phosphatase RapH inhibitor"
FT                   /id="PRO_0000388774"
FT   REGION          26..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..46
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        37..44
FT                   /note="RNTTYIDH -> PLESTAQA (in Ref. 4; AAA22831)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   57 AA;  6345 MW;  B237BF7F07B056C5 CRC64;
     MPIKKKVMMC LAVTLVFGSM SFPTLTNSGG FKESTDRNTT YIDHSPYKLS DQKKALS