ID   PHS1_CUPPJ              Reviewed;         116 AA.
AC   Q475Y4;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Putative pterin-4-alpha-carbinolamine dehydratase 1 {ECO:0000255|HAMAP-Rule:MF_00434};
DE            Short=PHS 1 {ECO:0000255|HAMAP-Rule:MF_00434};
DE            EC=4.2.1.96 {ECO:0000255|HAMAP-Rule:MF_00434};
DE   AltName: Full=4-alpha-hydroxy-tetrahydropterin dehydratase 1 {ECO:0000255|HAMAP-Rule:MF_00434};
DE   AltName: Full=Pterin carbinolamine dehydratase 1 {ECO:0000255|HAMAP-Rule:MF_00434};
DE            Short=PCD 1 {ECO:0000255|HAMAP-Rule:MF_00434};
GN   OrderedLocusNames=Reut_A0417;
OS   Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator
OS   (strain JMP 134)).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=264198;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JMP134 / LMG 1197;
RX   PubMed=20339589; DOI=10.1371/journal.pone.0009729;
RA   Lykidis A., Perez-Pantoja D., Ledger T., Mavromatis K., Anderson I.J.,
RA   Ivanova N.N., Hooper S.D., Lapidus A., Lucas S., Gonzalez B.,
RA   Kyrpides N.C.;
RT   "The complete multipartite genome sequence of Cupriavidus necator JMP134, a
RT   versatile pollutant degrader.";
RL   PLoS ONE 5:E9729-E9729(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC         (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00434};
CC   -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC       family. {ECO:0000255|HAMAP-Rule:MF_00434}.
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DR   EMBL; CP000090; AAZ59799.1; -; Genomic_DNA.
DR   RefSeq; WP_011296607.1; NC_007347.1.
DR   AlphaFoldDB; Q475Y4; -.
DR   SMR; Q475Y4; -.
DR   STRING; 264198.Reut_A0417; -.
DR   EnsemblBacteria; AAZ59799; AAZ59799; Reut_A0417.
DR   KEGG; reu:Reut_A0417; -.
DR   eggNOG; COG2154; Bacteria.
DR   HOGENOM; CLU_081974_2_2_4; -.
DR   OMA; FHHPGIL; -.
DR   OrthoDB; 1862336at2; -.
DR   GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1360.20; -; 1.
DR   HAMAP; MF_00434; Pterin_4_alpha; 1.
DR   InterPro; IPR036428; PCD_sf.
DR   InterPro; IPR001533; Pterin_deHydtase.
DR   Pfam; PF01329; Pterin_4a; 1.
DR   SUPFAM; SSF55248; SSF55248; 1.
PE   3: Inferred from homology;
KW   Lyase.
FT   CHAIN           1..116
FT                   /note="Putative pterin-4-alpha-carbinolamine dehydratase 1"
FT                   /id="PRO_0000231469"
SQ   SEQUENCE   116 AA;  12714 MW;  39F5F9632A781174 CRC64;
     MSEKLESQTC TPCRGGIPPL ERAEAEALLV ETPGWTLADD AGRLERSFTF RNFAQALEFV
     SGVGRLAEEQ GHHPEISFGW GHATVSWRTK KIKGLHRNDF VMAAKTSELA AGMTQG