PHSA_ARATH
ID PHSA_ARATH Reviewed; 482 AA.
AC Q9C6S4;
DT 05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Probable polyamine transporter At1g31820;
GN OrderedLocusNames=At1g31820; ORFNames=F5M6.17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Probable cell membrane polyamine/proton symporter involved in
CC the polyamine uptake in cells. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. Polyamine:cation symporter (PHS) (TC 2.A.3.12) family.
CC {ECO:0000305}.
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DR EMBL; AC079041; AAG50712.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31399.1; -; Genomic_DNA.
DR PIR; C86442; C86442.
DR RefSeq; NP_174465.1; NM_102919.4.
DR AlphaFoldDB; Q9C6S4; -.
DR SMR; Q9C6S4; -.
DR BioGRID; 25306; 3.
DR IntAct; Q9C6S4; 3.
DR STRING; 3702.AT1G31820.1; -.
DR PaxDb; Q9C6S4; -.
DR PRIDE; Q9C6S4; -.
DR ProteomicsDB; 236750; -.
DR EnsemblPlants; AT1G31820.1; AT1G31820.1; AT1G31820.
DR GeneID; 840072; -.
DR Gramene; AT1G31820.1; AT1G31820.1; AT1G31820.
DR KEGG; ath:AT1G31820; -.
DR Araport; AT1G31820; -.
DR TAIR; locus:2034461; AT1G31820.
DR eggNOG; KOG1287; Eukaryota.
DR HOGENOM; CLU_007946_17_3_1; -.
DR InParanoid; Q9C6S4; -.
DR OMA; TMFPING; -.
DR OrthoDB; 621852at2759; -.
DR PhylomeDB; Q9C6S4; -.
DR PRO; PR:Q9C6S4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C6S4; baseline and differential.
DR Genevisible; Q9C6S4; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015203; F:polyamine transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0015846; P:polyamine transport; IDA:TAIR.
DR InterPro; IPR002293; AA/rel_permease1.
DR InterPro; IPR044566; RMV1-like.
DR PANTHER; PTHR45826; PTHR45826; 1.
DR Pfam; PF13520; AA_permease_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..482
FT /note="Probable polyamine transporter At1g31820"
FT /id="PRO_0000418908"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 482 AA; 52599 MW; C99623F2AEF43525 CRC64;
MGDYNMNEFA YGNLYDDDDG DVGGSSKEGN NSIQKVSMLP LVFLIFYEVS GGPFGAEGSV
NAAGPLLALL GFVIFPFIWC IPEALITAEM STMFPINGGF VVWVSSALGT FWGFQVGWMK
WLCGVIDNAL YPVLFLDYLK SAVPALATGL PRVASILILT LLLTYLNYRG LTIVGWTAVF
MGVFSMLPFA VMSLVSIPQL EPSRWLVMDL GNVNWNLYLN TLLWNLNYWD SVSTLAGEVA
NPKKTLPKAL CYGVIFVALS NFLPLLSGTG AIPLDRELWT DGYLAEVAKA IGGGWLQLWV
QAAAATSNMG MFLAEMSSDS FQLLGMAELG ILPEIFAQRS RYGTPLLGIL FSASGVLLLS
GLSFQEIIAA ENLLYCGGMI LEFIAFVRLR KKHPAASRPY KIPVGTVGSI LICVPPIVLI
CLVIVLSTIK VALVSFVMVV IGFLMKPCLN HMDGKKWVKF SVCSDLAEFQ KENLDCEESL
LR
