ID   A53_VACCC               Reviewed;         103 AA.
AC   P21071;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   29-SEP-2021, entry version 72.
DE   RecName: Full=Truncated secreted TNF-receptor-like protein A53;
GN   ORFNames=A53R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- MISCELLANEOUS: The A53R protein from Western Reserve and Copenhagen
CC       strains are predicted to be inactive because of mutations that
CC       introduce stop codons or frameshifts when compared to other
CC       poxiviruses.
CC   -!- SIMILARITY: Belongs to the poxviridae A53R protein family.
CC       {ECO:0000305}.
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DR   EMBL; M35027; AAA48188.1; -; Genomic_DNA.
DR   PIR; A42523; A42523.
DR   SMR; P21071; -.
DR   Proteomes; UP000008269; Genome.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   Pfam; PF00020; TNFR_c6; 1.
DR   SMART; SM00208; TNFR; 1.
DR   PROSITE; PS00652; TNFR_NGFR_1; 1.
DR   PROSITE; PS50050; TNFR_NGFR_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Late protein; Reference proteome; Repeat.
FT   CHAIN           1..103
FT                   /note="Truncated secreted TNF-receptor-like protein A53"
FT                   /id="PRO_0000058940"
FT   REPEAT          36..73
FT                   /note="TNFR-Cys 1"
FT   REPEAT          74..103
FT                   /note="TNFR-Cys 2; truncated"
FT   DISULFID        37..50
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        51..64
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT   DISULFID        54..72
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ   SEQUENCE   103 AA;  12032 MW;  87C3C68B5D1289CD CRC64;
     MIILKDGYKE FADCMYYFLH YYIGYGRYTY SATNGSCDKG EYLDKRHNQC CNRCPPGEFA
     KVRCNGNDNT KCERCPPHTY TTIPIILMDV INVENAQQDH LIR