ID   PHSL_DESNO              Reviewed;          19 AA.
AC   P13066;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Periplasmic [NiFeSe] hydrogenase large subunit;
DE            EC=1.12.99.6;
DE   AltName: Full=NiFeSe hydrogenlyase large chain;
DE   Flags: Fragment;
OS   Desulfomicrobium norvegicum (strain DSM 1741 / NCIMB 8310) (Desulfovibrio
OS   baculatus (strain Norway 4)) (Desulfovibrio desulfuricans (strain Norway
OS   4)).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales;
OC   Desulfomicrobiaceae; Desulfomicrobium.
OX   NCBI_TaxID=52561;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3322275; DOI=10.1016/0006-291x(87)90376-7;
RA   Prickril B.C., He S.H., Li C., Menon N.K., Choi E.S., Przybyla A.E.,
RA   Dervartanian D.V., Peck H.D. Jr., Fauque G., le Gall J., Teixeira M.,
RA   Moura I., Moura J.J.G., Patil D., Huynh B.H.;
RT   "Identification of three classes of hydrogenase in the genus,
RT   Desulfovibrio.";
RL   Biochem. Biophys. Res. Commun. 149:369-377(1987).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + H2 = AH2; Xref=Rhea:RHEA:12116, ChEBI:CHEBI:13193,
CC         ChEBI:CHEBI:17499, ChEBI:CHEBI:18276; EC=1.12.99.6;
CC   -!- COFACTOR:
CC       Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC   -!- SUBUNIT: Heterodimer of a large and a small subunit.
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- SIMILARITY: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit
CC       family. {ECO:0000305}.
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DR   PIR; H27480; H27480.
DR   AlphaFoldDB; P13066; -.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0033748; F:hydrogenase (acceptor) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Iron; Metal-binding; Nickel; Oxidoreductase;
KW   Periplasm.
FT   CHAIN           1..>19
FT                   /note="Periplasmic [NiFeSe] hydrogenase large subunit"
FT                   /id="PRO_0000199705"
FT   NON_TER         19
SQ   SEQUENCE   19 AA;  1942 MW;  2BFCD2D360F00367 CRC64;
     AQAATPAADG KKKISIDTR