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PHS_AQUAE
ID   PHS_AQUAE               Reviewed;          99 AA.
AC   O66462;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Putative pterin-4-alpha-carbinolamine dehydratase;
DE            Short=PHS;
DE            EC=4.2.1.96;
DE   AltName: Full=4-alpha-hydroxy-tetrahydropterin dehydratase;
DE   AltName: Full=Pterin carbinolamine dehydratase;
DE            Short=PCD;
GN   OrderedLocusNames=aq_049;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC         (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC   -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; AE000657; AAC06420.1; -; Genomic_DNA.
DR   PIR; C70304; C70304.
DR   RefSeq; NP_213022.1; NC_000918.1.
DR   RefSeq; WP_010879960.1; NC_000918.1.
DR   AlphaFoldDB; O66462; -.
DR   SMR; O66462; -.
DR   STRING; 224324.aq_049; -.
DR   EnsemblBacteria; AAC06420; AAC06420; aq_049.
DR   KEGG; aae:aq_049; -.
DR   eggNOG; COG2154; Bacteria.
DR   HOGENOM; CLU_081974_4_0_0; -.
DR   InParanoid; O66462; -.
DR   OMA; NFAQMVG; -.
DR   OrthoDB; 1862336at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IBA:GO_Central.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1360.20; -; 1.
DR   HAMAP; MF_00434; Pterin_4_alpha; 1.
DR   InterPro; IPR036428; PCD_sf.
DR   InterPro; IPR001533; Pterin_deHydtase.
DR   PANTHER; PTHR12599; PTHR12599; 1.
DR   Pfam; PF01329; Pterin_4a; 1.
DR   SUPFAM; SSF55248; SSF55248; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..99
FT                   /note="Putative pterin-4-alpha-carbinolamine dehydratase"
FT                   /id="PRO_0000063070"
SQ   SEQUENCE   99 AA;  11581 MW;  6C65B8D7296470F8 CRC64;
     MVRKLSEEEV KRELENLEGW EFCKDYIQKE FSTKNWKTTI FVVNAIASLA EAQWHHPDLE
     VSFKKVKVKL TTHEAGGITE RDIKLAKSID ELVKEILKH
 
 
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