ID   PHS_CAEEL               Reviewed;         142 AA.
AC   Q9TZH6;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 3.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Putative pterin-4-alpha-carbinolamine dehydratase;
DE            Short=PHS;
DE            EC=4.2.1.96;
DE   AltName: Full=4-alpha-hydroxy-tetrahydropterin dehydratase;
DE   AltName: Full=Pterin carbinolamine dehydratase;
DE            Short=PCD;
GN   Name=pcbd-1; ORFNames=T10B11.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC         (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC   -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; FO080731; CCD66239.1; -; Genomic_DNA.
DR   PIR; T33522; T33522.
DR   RefSeq; NP_491982.2; NM_059581.5.
DR   AlphaFoldDB; Q9TZH6; -.
DR   SMR; Q9TZH6; -.
DR   STRING; 6239.T10B11.1; -.
DR   EPD; Q9TZH6; -.
DR   PaxDb; Q9TZH6; -.
DR   PeptideAtlas; Q9TZH6; -.
DR   EnsemblMetazoa; T10B11.1.1; T10B11.1.1; WBGene00020397.
DR   GeneID; 188368; -.
DR   KEGG; cel:CELE_T10B11.1; -.
DR   UCSC; T10B11.1; c. elegans.
DR   CTD; 188368; -.
DR   WormBase; T10B11.1; CE39768; WBGene00020397; pcbd-1.
DR   eggNOG; KOG4073; Eukaryota.
DR   GeneTree; ENSGT00390000007221; -.
DR   HOGENOM; CLU_081974_3_0_1; -.
DR   InParanoid; Q9TZH6; -.
DR   OMA; FMTRVGL; -.
DR   OrthoDB; 1588292at2759; -.
DR   PhylomeDB; Q9TZH6; -.
DR   Reactome; R-CEL-8964208; Phenylalanine metabolism.
DR   PRO; PR:Q9TZH6; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00020397; Expressed in larva and 4 other tissues.
DR   GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IBA:GO_Central.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1360.20; -; 1.
DR   HAMAP; MF_00434; Pterin_4_alpha; 1.
DR   InterPro; IPR036428; PCD_sf.
DR   InterPro; IPR001533; Pterin_deHydtase.
DR   PANTHER; PTHR12599; PTHR12599; 1.
DR   Pfam; PF01329; Pterin_4a; 1.
DR   SUPFAM; SSF55248; SSF55248; 1.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..142
FT                   /note="Putative pterin-4-alpha-carbinolamine dehydratase"
FT                   /id="PRO_0000063060"
SQ   SEQUENCE   142 AA;  16255 MW;  8AD47F7D814E8EEF CRC64;
     MHSSYSHFLQ RLRTSVSYLS VSHFPSTSSH RLFSTTIGVF ARKKMPLLTE SERTEQLSGL
     KTAGWKLVEG RDAIQKEFHF KDFNEAFGFM TRVGLKAEKM DHHPEWFNVY NKVDITLSTH
     DCGGLSPNDV KLATFIESIV KK