ID   PHS_DROVI               Reviewed;         101 AA.
AC   P58249;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   29-AUG-2001, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Pterin-4-alpha-carbinolamine dehydratase;
DE            Short=PHS;
DE            EC=4.2.1.96;
DE   AltName: Full=4-alpha-hydroxy-tetrahydropterin dehydratase;
DE   AltName: Full=Pterin carbinolamine dehydratase;
DE            Short=PCD;
GN   Name=Pcd;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11710527;
RA   Park H., Seong C., Jang J., Yoon J., Han K., Cho N.Y., Baek K.;
RT   "Promoter analysis of the Drosophila melanogaster gene encoding the pterin
RT   4alpha-carbinolamine dehydratase.";
RL   Mol. Cells 12:233-238(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC         (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC   -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF382144; AAK60268.1; -; Genomic_DNA.
DR   AlphaFoldDB; P58249; -.
DR   SMR; P58249; -.
DR   STRING; 7244.FBpp0225049; -.
DR   eggNOG; KOG4073; Eukaryota.
DR   GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1360.20; -; 1.
DR   HAMAP; MF_00434; Pterin_4_alpha; 1.
DR   InterPro; IPR036428; PCD_sf.
DR   InterPro; IPR001533; Pterin_deHydtase.
DR   PANTHER; PTHR12599; PTHR12599; 1.
DR   Pfam; PF01329; Pterin_4a; 1.
DR   SUPFAM; SSF55248; SSF55248; 1.
PE   3: Inferred from homology;
KW   Lyase.
FT   CHAIN           1..101
FT                   /note="Pterin-4-alpha-carbinolamine dehydratase"
FT                   /id="PRO_0000063062"
SQ   SEQUENCE   101 AA;  11646 MW;  B4B49DF4FFAE70C9 CRC64;
     MVAKLTEQER VEKLQPLLDA GWCLVEGRDA IYKEFLFKDF NQAFSFMTGV ALLAEKMNHH
     PEWFNVYNKL QVTLSTHDVG GLSSQDIRMA TYLETQAKLL H