ID   PHS_HYPDU               Reviewed;         103 AA.
AC   P0C8L6;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Probable pterin-4-alpha-carbinolamine dehydratase;
DE            Short=PHS;
DE            EC=4.2.1.96;
DE   AltName: Full=4-alpha-hydroxy-tetrahydropterin dehydratase;
DE   AltName: Full=Pterin carbinolamine dehydratase;
DE            Short=PCD;
GN   Name=Pcd;
OS   Hypsibius dujardini (Water bear) (Macrobiotus dujardini).
OC   Eukaryota; Metazoa; Ecdysozoa; Tardigrada; Eutardigrada; Parachela;
OC   Hypsibioidea; Hypsibiidae; Hypsibius.
OX   NCBI_TaxID=232323;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Sciento Z151;
RA   Daub J., Thomas F., Aboobaker A., Blaxter M.L.;
RT   "A survey of genes expressed in the tardigrade Hypsibius dujardini.";
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in tetrahydrobiopterin biosynthesis. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC         (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC   -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC       family. {ECO:0000305}.
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DR   EMBL; CK326948; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0C8L6; -.
DR   SMR; P0C8L6; -.
DR   OMA; WAEKWNH; -.
DR   GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1360.20; -; 1.
DR   HAMAP; MF_00434; Pterin_4_alpha; 1.
DR   InterPro; IPR036428; PCD_sf.
DR   InterPro; IPR001533; Pterin_deHydtase.
DR   PANTHER; PTHR12599; PTHR12599; 1.
DR   Pfam; PF01329; Pterin_4a; 1.
DR   SUPFAM; SSF55248; SSF55248; 1.
PE   3: Inferred from homology;
KW   Lyase; Tetrahydrobiopterin biosynthesis.
FT   CHAIN           1..103
FT                   /note="Probable pterin-4-alpha-carbinolamine dehydratase"
FT                   /id="PRO_0000357456"
SQ   SEQUENCE   103 AA;  11706 MW;  EB5ECBADB3987B8C CRC64;
     MDPRLTHEDR ILHLAPLTEK GWLLVEGRDA IHKEFKFKDF NAAFGFMTRV ALLAEKMDHH
     PEWFNVYNKV QITLSSHDVA GLSQRDIKLA SFIEKAAVGA STS