PHS_SCHPO
ID PHS_SCHPO Reviewed; 96 AA.
AC O42658;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=Pterin-4-alpha-carbinolamine dehydratase;
DE Short=PHS;
DE EC=4.2.1.96;
DE AltName: Full=4-alpha-hydroxy-tetrahydropterin dehydratase;
DE AltName: Full=Overlapping meiotic transcript 2;
DE AltName: Full=Pterin carbinolamine dehydratase;
DE Short=PCD;
GN Name=omt2; ORFNames=SPAC27D7.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=12786945; DOI=10.1046/j.1365-2443.2003.00654.x;
RA Kakihara Y., Nabeshima K., Hirata A., Nojima H.;
RT "Overlapping omt1+ and omt2+ genes are required for spore wall maturation
RT in Schizosaccharomyces pombe.";
RL Genes Cells 8:547-558(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Has a role in spore wall formation.
CC {ECO:0000269|PubMed:12786945}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC -!- SUBCELLULAR LOCATION: Spore wall {ECO:0000269|PubMed:12786945}.
CC Note=Inner spore wall.
CC -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC family. {ECO:0000305}.
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DR EMBL; CU329670; CAA15823.1; -; Genomic_DNA.
DR PIR; T38437; T38437.
DR RefSeq; NP_594610.1; NM_001020038.4.
DR AlphaFoldDB; O42658; -.
DR SMR; O42658; -.
DR BioGRID; 278114; 12.
DR IntAct; O42658; 2.
DR STRING; 4896.SPAC27D7.04.1; -.
DR iPTMnet; O42658; -.
DR MaxQB; O42658; -.
DR PaxDb; O42658; -.
DR EnsemblFungi; SPAC27D7.04.1; SPAC27D7.04.1:pep; SPAC27D7.04.
DR GeneID; 2541617; -.
DR KEGG; spo:SPAC27D7.04; -.
DR PomBase; SPAC27D7.04; omt2.
DR VEuPathDB; FungiDB:SPAC27D7.04; -.
DR eggNOG; KOG4073; Eukaryota.
DR HOGENOM; CLU_081974_3_2_1; -.
DR InParanoid; O42658; -.
DR OMA; LTHKDIS; -.
DR PhylomeDB; O42658; -.
DR Reactome; R-SPO-8964208; Phenylalanine metabolism.
DR PRO; PR:O42658; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0042764; C:ascospore-type prospore; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0031160; C:spore wall; IEA:UniProtKB-SubCell.
DR GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; ISM:PomBase.
DR GO; GO:0030437; P:ascospore formation; IMP:PomBase.
DR GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR Gene3D; 3.30.1360.20; -; 1.
DR HAMAP; MF_00434; Pterin_4_alpha; 1.
DR InterPro; IPR036428; PCD_sf.
DR InterPro; IPR001533; Pterin_deHydtase.
DR PANTHER; PTHR12599; PTHR12599; 1.
DR Pfam; PF01329; Pterin_4a; 1.
DR SUPFAM; SSF55248; SSF55248; 1.
PE 3: Inferred from homology;
KW Lyase; Reference proteome.
FT CHAIN 1..96
FT /note="Pterin-4-alpha-carbinolamine dehydratase"
FT /id="PRO_0000063063"
SQ SEQUENCE 96 AA; 11101 MW; 09113B5FB3DF9F4F CRC64;
MNTSARLLAL VSKSKNNWIL QQGDTKLFKS FRFKNFIEAW GFMSCVALRA QQLNHHPEWT
NVYNKVDITL TTHDTKGLTE KDLKLAEFID TLAKDN
