ID   A57_VACCC               Reviewed;         151 AA.
AC   P21074;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 3.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Guanylate kinase homolog;
GN   ORFNames=A57R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- SIMILARITY: Belongs to the guanylate kinase family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48193.1; -; Genomic_DNA.
DR   PIR; E42523; E42523.
DR   SMR; P21074; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
PE   3: Inferred from homology;
KW   Kinase; Reference proteome; Transferase.
FT   CHAIN           1..151
FT                   /note="Guanylate kinase homolog"
FT                   /id="PRO_0000170656"
FT   DOMAIN          1..141
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00100"
SQ   SEQUENCE   151 AA;  17448 MW;  85C0E1D0DCD8320A CRC64;
     MEREGVDYHY VNREAIWKGI AAGNFLEHTE FLGNIYGTSK TAVNTAAINN RICVMDLNID
     GVRSFKNTYL MPYSVYIRPT SLKMVETKLR CRNTEANDEI HRRVILAKTD MDEANEAGLF
     DTIIIEDDVN LAYSKLIQIL QDRIRMYFNT N