ID   PHT4_PSEPU              Reviewed;         410 AA.
AC   Q05184;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Putative 4,5-dihydroxyphthalate dehydrogenase;
DE            Short=DHP dehydrogenase;
DE            EC=1.-.-.-;
GN   Name=pht4;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OG   Plasmid PHT.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NMH102-2;
RA   Nomura Y., Nakagawa M., Ogawa N., Harashima S., Oshima Y.;
RT   "Genes in PHT plasmid encoding the initial degradation pathway of phthalate
RT   in Pseudomonas putida.";
RL   J. Ferment. Bioeng. 74:333-344(1992).
CC   -!- FUNCTION: Transforms 4,5-dihydro-4,5-dihydroxyphthalate to 4,5-
CC       dihydroxyphthalate.
CC   -!- PATHWAY: Xenobiotic degradation; phthalate degradation; 3,4-
CC       dihydroxybenzoate from phthalate: step 2/3.
CC   -!- INDUCTION: Induced by phthalate and repressed by glucose.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D13229; BAA02512.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q05184; -.
DR   SMR; Q05184; -.
DR   KEGG; ag:BAA02512; -.
DR   UniPathway; UPA00726; UER00729.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046239; P:phthalate catabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR   InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01408; GFO_IDH_MocA; 1.
DR   Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Aromatic hydrocarbons catabolism; Oxidoreductase; Plasmid.
FT   CHAIN           1..410
FT                   /note="Putative 4,5-dihydroxyphthalate dehydrogenase"
FT                   /id="PRO_0000058409"
SQ   SEQUENCE   410 AA;  45644 MW;  0D1A95B019DCAC1A CRC64;
     MMASHAESTA RLRLGVVGLG RAFTLMLPTF LADRRVQLVG ACDPREQARR QFERDFDAPA
     YETIEDLAAD SNVDALYIAS PHQFHAEHTR IAAANRKHVL VEKPMALSLD ECDRMIADCA
     EAGVKLIVGH CHSFDTPYLR TRELIGSGEF GAVKMIQALN YTDYLQRPRR PEELSTAEGG
     GAVFSQAAHQ VDVVRLLAGS RATRVRAAVG NWDPARPTEG AYTATLWFEN GAFASITYNG
     YGHFDSDEWM DWVGEMGKPK NPEAYGGARR LLQQVQTADE EARLKAEGTY GGTRYVSPSP
     TDDATAFQHF GPIIVSCEGG DLRPMADAVM IYRPHSRDRM MLERPTVPRS EVIDELYLAQ
     FYGVTPLHDG EWARDTLEIC LAMLRSSEEQ RDITLGVNVE DTQWRENPSS