ID   PHT5_PSEPU              Reviewed;         258 AA.
AC   Q05185;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=4,5-dihydroxyphthalate decarboxylase;
DE            Short=DHP decarboxylase;
DE            EC=4.1.1.55;
GN   Name=pht5;
OS   Pseudomonas putida (Arthrobacter siderocapsulatus).
OG   Plasmid PHT.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=303;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NMH102-2;
RA   Nomura Y., Nakagawa M., Ogawa N., Harashima S., Oshima Y.;
RT   "Genes in PHT plasmid encoding the initial degradation pathway of phthalate
RT   in Pseudomonas putida.";
RL   J. Ferment. Bioeng. 74:333-344(1992).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4,5-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2;
CC         Xref=Rhea:RHEA:24184, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:36241, ChEBI:CHEBI:58051; EC=4.1.1.55;
CC   -!- PATHWAY: Xenobiotic degradation; phthalate degradation; 3,4-
CC       dihydroxybenzoate from phthalate: step 3/3.
CC   -!- INDUCTION: Induced by phthalate and repressed by glucose.
CC   -!- SIMILARITY: To P.testosteroni DHP decarboxylase. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D13229; BAA02513.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q05185; -.
DR   KEGG; ag:BAA02513; -.
DR   UniPathway; UPA00726; UER00730.
DR   GO; GO:0018796; F:4,5-dihydroxyphthalate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046239; P:phthalate catabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR015168; SsuA/THI5.
DR   Pfam; PF09084; NMT1; 1.
PE   2: Evidence at transcript level;
KW   Aromatic hydrocarbons catabolism; Decarboxylase; Lyase; Plasmid.
FT   CHAIN           1..258
FT                   /note="4,5-dihydroxyphthalate decarboxylase"
FT                   /id="PRO_0000058410"
SQ   SEQUENCE   258 AA;  28580 MW;  575CEDAA43D31AE6 CRC64;
     MAREPIIMNK LNLSIAVGNY VRIRPLVDGE VQIDGVDPIF MLQDPEEIFF RAFRHADYDI
     CELSLSSYSV KTAAGTSPYI AVPVFPSRAF RHTSIYIRND RGIESAADLK GKRIGVPEYQ
     LTANVWVRLF LEEDHGLKAS DVTWVRGGYE ETGRLEKIVL KLPADVIVEN APETETLSGM
     LASGELDAVI GPRAPSCFTQ GHPKVSYLYR DPQGAASDWY RALSYSRSCT CWGSGARWPS
     STLGYPGPLP KHSRSPSP